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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1999.6
- 수록면
- 191 - 197 (7page)
이용수
초록· 키워드
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To determine changes in the central glutamatergic nervous activities following chronic lead-exposure rats were continuously treated from mating to 4 week-old of the second generation with 0.25% lead acetate in their drinking water. As the pups became 4-week old, the levels of glutamate and glutamine, the activities of various glutamate metabolizing enzymes and the specific binding of [³H]MK-801 to NMDA receptors were determined in striatum, hippocampus and frontal cortex. The total levels of glutamate were not changed in all examined regions after lead-exposure. However, the concentration of glutamine was only decreased in hippocampus. The activities of glutamate dehydrogenase and glutaminase were decreased and increased, respectively. But the activities of glutamine synthetase did not alter in all examined regions after the lead exposure. The specific binding of [³H]MK-801 were significantly increased in the striatum and decreased in the frontal cortex and hippocampus after the chronic lead treatment. These results indicate that the central glutamatergic nervous systems may be affected with the chronic lead-exposure. Furthermore, these results suggest that the toxic effects of lead to the glutamatergic nervous activity are region-dependent and the hippocamus may be the one of the major target site.
목차
ABSTRACT
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과
Ⅳ. 고찰
감사의 말씀
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