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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1999.9
- 수록면
- 363 - 367 (5page)
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초록· 키워드
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Cordyceps militaris is one of the parasitic fungi Cordyceps sp. and used for Chinese traditional herbal medicine. Some components of Cordyceps sinensis extract such as cordycepin, certain polysaccharides and even it's crude extract are significantly effective on the immune system, enzyme inhibition, reveal anticancer and antifungal activity in animal experimental system. Protecting activity of Cordyceps militaris extract (CME) against DNA damage and antimutagenic activity of CME were investigated in microbial test system and in DNA fragmentation experiment. CME inhibited not only chromosomal DNA damage in E. coli, but also daunorubicin-induced plasmid DNA damage. It was observed that DNA damage inhibition in vitro by CME resulted from the inactivation of daunorubicin by CME, but not from cellular DNA protection by CME. In vivo mutagenicity test system in E. coli, CME did not repair DNA damage induced by 4-nitroquinoline-n-oxide (4NQO), but it caused the 4NQO inactivation which leads to inhibit 4NQO-induced β-galactosidase synthesis in SOS-chromotest. From the correlation between the inhibition of in vitro DNA fragmentation with the inhibition of cellular DNA damage in vivo, it is suggested that CME has an inhibitory effect on the DNA damaging action of daunorubicin and on the mutagenicity of 4NQO in E. coli test system.
목차
ABSTRACT
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과 및 고찰
감사의 글
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Molecular & cellular toxicology
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대한약학회 학술대회
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Activation Mechanism of Protein Kinase B by DNA-dependent Protein Kinase Involved in the DNA Repair System
Toxicological Research
2008 .09
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국내 정형외과학회의 의학연수교육에 대한 인식도 평가
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환경성 유해요인이 유전물질과 세포활성에 미치는 영향 Ⅲ. 포유동물세포에서 돌연변이원에 의한 DNA 상해의 회복에 미치는 DNA 중합효소저해제의 영향 ( Environmental Toxic Agents on Genetic Material and Cellular Activity III. DNA Polymerase Inhibitors on Repair of Mutagen-Induced DNA Damage in Mammalian Cells )
한국환경성돌연변이·발암원학회지
1988 .03
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UCI(KEPA) : I410-ECN-0101-2009-513-013745976