지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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In order to determine the functional benefits of Cordyceps militaris in the immune system, we examined the immunomodulatory activities of C. militaris using an immunocompromised C57BL/6 mice, mouse spleen cells, RAW 264.7 macrophage cells, and A549 lung carcinoma cells. Mice were injected intraperitioneally with an immunosuppressive drug, cyclophosphamide, and then administered orally with 30, 100 and 300 mg/kg of 50% ethanol extract of C. militaris (CME 30, CME 100 and CME 300) for 14 days. CME increased splenocyte proliferation and natural killer (NK) cell activity compared to 3% hydroxypropyl methylcellulose-treated control mice. CME also increased the production of Th1 cytokines, IL-2 and TNF-${\alpha}$ in spleen cells isolated from CME-injected mice and in vitro, which suggested the enhanced cellular immunity in response to CME. CME also increased splenocyte proliferation, NK cell activity, and IL-2 and TNF-${\alpha}$ production compared to 1 ${\mu}M$ methotrexate-treated spleen cells in vitro. We examined whether C. militaris regulates the production of inflammatory mediators in LPS-stimulated RAW 264.7 cells. CME inhibited LPS-induced NO production and iNOS expression in a dose dependent manner, while COX-2 expression was remained unchanged. In addition, CME also has free radical scavenging activity, indicating its antioxidant activity. These results indicate that C. militaris enhances immune activity by promoting immune cell proliferation and cytokine production.
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참고문헌 (41)
참고문헌 신청
Sung, G. H. / 2007 / Phylogenetic classification of Cordyceps and the clavicipitaceous fungi / Stud. Mycol 57:5
성한수 / 1996 / 한국의 동충하초 / 교학사 :13
Jang, Y. S. / 1986 / Notes on unrecorded fresh fungi of Cordyceps in Korea / Kor. J. Mycol 14:85
Sung, J. M. / 1993 / Studies on distribution and utilization of Cordyceps militaris and C. nutans / Kor. J. Mycol 21:94
Sung, J. M. / 1998 / Classification of Cordyceps species based on protein banding pattern / Kor. J. Mycol 26:1
성한수 / 1996 / 한국의 동충하초 / 교학사 :13
Jang, Y. S. / 1986 / Notes on unrecorded fresh fungi of Cordyceps in Korea / Kor. J. Mycol 14:85
Sung, J. M. / 1993 / Studies on distribution and utilization of Cordyceps militaris and C. nutans / Kor. J. Mycol 21:94
Sung, J. M. / 1998 / Classification of Cordyceps species based on protein banding pattern / Kor. J. Mycol 26:1
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