지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.9
- 수록면
- 217 - 225 (9page)
이용수
초록· 키워드
오류제보하기
Changes of plasma DNA contents and serum biochemical values were measured in rats administered with lead acetate to investigate the in vivo cytotoxic effects of lead and examine the usefulness of these in vivo cytotoxicity changes as indicators of lead exposure and diagnosis of lead poisoning. Rats were given once intraperitonealy with lead acetate (1.6, 8, 40 and 200 mg/kg b.w)
and the changes of plasma DNA contents and serum biochemical values were measured at the time of 2, 4, 8, 24, 48 and 72 hours after the administration of lead acetate. Plasma DNA contents began to increase at 2 hours after the administration of lead acetate in the treatment groups of 8, 40 and 200 mg/kg b.w dose-dependently and significantly compared with control group. These DNA increases of each dosage group were continued until 24, 48 and 72 hours and the maximum levels of DNA (4.02, 10.67 and 14.10 times of control) were arrived at 8, 8 and 4 hours after the each treatment, respectively. Among 10 serum biochemical indicators, the activities of creatine kinase were increased to maximum level (6.55 times of control) at 2 hours after the administration and remained to be significantly higher than that of control by 8 hours in the treatment group of 200 mg, however, after 48 hours, the levels in the treatment groups of 40 mg above were lower than that of control. The values
of aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase were higher than that of control from 2 to 24 hours in the treatment group of 200 mg. Maximum levels of these enzymes were 3.34, 3.00 and 3.19 times of control, respectively. Both of alkaline phosphatase and triglyceride values in the treatment groups were decreased compared with control. In the case of alkaline phosphatse, the values were significanly decreased from 24 hours and more severely decreased until 72 hours in the treatment groups of 40 mg above (p<0.01). The minimum value was 0.36 times
of control in the 200 mg group. The values of triglyceride were significantly decreased in the tratment groups of 40 mg above (p<0.01), but the values were not different significantly among the treatment groups. This study demonstrates that plasma DNA content and serum biochemical values such as aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase and triglyceride are valuable as biomarkers for exposure assessment and diagnosis of lead poisoning.
and the changes of plasma DNA contents and serum biochemical values were measured at the time of 2, 4, 8, 24, 48 and 72 hours after the administration of lead acetate. Plasma DNA contents began to increase at 2 hours after the administration of lead acetate in the treatment groups of 8, 40 and 200 mg/kg b.w dose-dependently and significantly compared with control group. These DNA increases of each dosage group were continued until 24, 48 and 72 hours and the maximum levels of DNA (4.02, 10.67 and 14.10 times of control) were arrived at 8, 8 and 4 hours after the each treatment, respectively. Among 10 serum biochemical indicators, the activities of creatine kinase were increased to maximum level (6.55 times of control) at 2 hours after the administration and remained to be significantly higher than that of control by 8 hours in the treatment group of 200 mg, however, after 48 hours, the levels in the treatment groups of 40 mg above were lower than that of control. The values
of aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase were higher than that of control from 2 to 24 hours in the treatment group of 200 mg. Maximum levels of these enzymes were 3.34, 3.00 and 3.19 times of control, respectively. Both of alkaline phosphatase and triglyceride values in the treatment groups were decreased compared with control. In the case of alkaline phosphatse, the values were significanly decreased from 24 hours and more severely decreased until 72 hours in the treatment groups of 40 mg above (p<0.01). The minimum value was 0.36 times
of control in the 200 mg group. The values of triglyceride were significantly decreased in the tratment groups of 40 mg above (p<0.01), but the values were not different significantly among the treatment groups. This study demonstrates that plasma DNA content and serum biochemical values such as aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase and triglyceride are valuable as biomarkers for exposure assessment and diagnosis of lead poisoning.
목차
ABSTRACT
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Factors Affecting DNA Yields from Serum and Plasma Samples Used for Personal Identification Testing
대한법의학회지
2016 .01
-
Long Working Hours and Emotional Well-Being in Korean Manufacturing Industry Employees
대한직업환경의학회지
2013 .12
-
실험적 간장해에 대한 강활의 보호효과
Environmental Analysis Health and Toxicology
2005 .06
-
The Association between Long Working Hours and Self-Rated Health
대한직업환경의학회지
2014 .01
-
Effect of Burn on the Cardiac Function in Rats
대한의생명과학회지
2002 .03
-
간호 · 간병통합서비스 병동 환자의 중증도 · 간호필요도에 따른 기대 간호시간 추정과 실제 간호시간과의 비교
간호행정학회지
2020 .09
-
Association between long working hours and serum gamma-glutamyltransferase levels in female workers : data from the fifth Korean National Health and Nutrition Examination Survey (2010-2011)
대한직업환경의학회지
2014 .12
-
혈장 중 납의 만성독성 지표로의 활용에 관한 연구
한국산업보건학회지
2019 .01
-
UVB 조사로 인한 마우스 피부조직의 산화적 손상
Environmental Analysis Health and Toxicology
2006 .06
-
방사선 조사가 백서 악하선 줄무늬관세포에 미치는 영향에 관한 투과전자현미경적 연구
치과방사선
1990 .01
-
장시간 근로와 산업재해와의 관계
한국직업건강간호학회지
2014 .01
-
새로운 Anthracycline계 항암성 항생물질 DA-125의 랫드에 대한 4주 용량설정시험(DRF)과 13주 아급성 독성시험
The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology
1994 .01
-
Study on the Changes in the Blood Lipid Profile Levels of Patients with Metabolic Syndrome while Receiving Oriental Medicine Treatments for Various Diseases
동의생리병리학회지
2009 .01
-
한약복용이 한방병원 입원환자의 간 기능에 미치는 영향에 대한 후향적 관찰
대한한방내과학회지
2019 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
폐광산 인근 토양, 지하수, 백미 중 비소, 카드뮴, 납 노출에 의한 독성 및 위해성평가
이지호
,
김원일
,
정은정
외 5명
한국토양비료학회 학술발표회 초록집
2011
.10
우리나라 성인의 혈중 카드뮴과 골밀도와의 관계
범은애
,
하미나
환경독성보건학회 심포지엄 및 학술대회
2012
.05
한국 수계형 확률생태위해성평가를 이용한 카드뮴 생태보호농도 도출
남선화
,
이우미
,
안윤주
환경독성보건학회 심포지엄 및 학술대회
2012
.05
혈중 납 농도와 어린이의 치아우식과의 관련성에 관한 체계적 문헌고찰
김영숙
,
하미나
환경독성보건학회 심포지엄 및 학술대회
2011
.10
생활환경 다매체/다경로를 통한 납에 대한 개인노출평가
설휘수
,
김찬국
,
박진호
외 2명
환경독성보건학회 심포지엄 및 학술대회
2011
.10
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-513-013745709