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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.12
- 수록면
- 411 - 416 (6page)
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초록· 키워드
오류제보하기
Apoptosis, or programmed cell death, is a genetically regulated pathway that is altered in many cancers. Overexpression of bcl-2 leads to resistance to apoptosis and promotes tumorigenesis. To determine the effects of bcl-2 antisense treatment in human lung cancer cell lines, a 20 mer full phosphorothioate oligonucleotide (ODN) targeted at the coding region of the bcl-2 mRNA was synthesized. Western blot analyses were used to examine bcl-2 protein level in five human non-small cell lung cancer (NSCLC) cell lines (NCI-H226, SK-MES-1, NCI-H358, NCI-H522 and NCI-H1299) and four human small cell lung cancer (SCLC) cell lines (NCI-H69, NCI-H417, HCC-2108 and SW2). Three out of five NSCLC (NCI-H226, KS-MES-1 and NCI-H1299) and all of SCLC cell lines expressed Bcl-2 protein. Treatment of these cells with antisense ODN for 48 hours reduced their viability and Bcl-2 protein levels. As a conclusion, bcl-2 antisense treatment appears reduction of the Bcl-2 protein levels and cytotoxic effect including apoptosis in human lung cacer cell lines.
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UCI(KEPA) : I410-ECN-0101-2009-513-013456681