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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
동아시아식생활학회 동아시아식생활학회지 동아시아식생활학회지 제12권 제4호
발행연도
2002.8
수록면
289 - 298 (10page)

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This study was designed to investigate the anti-tumor effects of fresh carrot juice, methanol-extracts, and β-carotene on the human lung cancer cell line NCI-H1299. The anti-tumor effect was evaluated by the MTT assay in vitro. The anti-tumor effect of fresh carrot juice against NCI-H1299 lasted up to 96 hours after exposure; the viability rate of lung cancer cells decreased below 50% after 48 hours, and further after 72 hours. The strongest propagation inhibition effect of fresh carrot juice was shown at the concentration of 2000㎍/ml after 72 hours and the viability rates was 45.98% even at the concentration of 25㎍/ml. The value of IC_50 was 23.1㎍/ml when the elapsed time was 72 hours.
The viability rate of methanol-extract was 52.4% under the concentration of 2000 ㎍/ml and the elapsed time of 72 hours. Under the concentration of 1000 ㎍/ml and the elapsed time of 48 hours. β-carotene decreased the viability rate to 29.99%. The IC_50 value of β-carotene was 691.2㎍/ml after 72 hours. According to the above results, the anti-tumor effect arose in NCI-H1299 when the concentration of the fresh carrot juice or the β-carotene was more than 25㎍/ml or 1000㎍/ml, respectively. On the other hand, the methanol-extracts showed a weak anti-tumor effect even at a concentration as high as 2000㎍/ml.

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