지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 박재우, 지영흔
- 발행연도
- 2015
- 저작권
- 제주대학교 논문은 저작권에 의해 보호받습니다.
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초록· 키워드
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When exposed to gamma-rays, hair follicle stem cells, immediately go
through apoptosis, which injures their rapid differentiation essential for the
regeneration of hair. Phloroglucinol (PG) is a phenolic compound of Ecklonia
cava, brown algae abundant in Jeju island, Korea. Containing plentiful
polyphenol, PG is known for its instructive effects by inhibiting apoptosis,
scavenging oxygen radicals, and protecting cells against oxidative stress. In
this study, we demonstrate that PG rescues radiosensitive hair follicle stem
cells from gamma radiation-induced apoptosis and DNA damage. To identify
the hair follicle protection capability of PG, we irradiated gamma-rays to the
whole body of C57BL/6 mice at day 6 after depilation with or without PG.
PG or EpiCeram (EC) was applied once at 17.8 hours before irradiation and,
after irradiation, it was applied at 17.8 hours internals until autopsy. At 8
hours after gamma-rays irradiation, PG not only decreased apoptosis which
was suppressed by radiation as shown in control but also decreased
morphlogical changes of hair follicles. Our results suggest that PG presents
radioprotective effects by inhibiting apoptosis of radiosensitive hair follicle stem cells and can PG protects hair follicle stem cells from gamma-ray
induced damage.
through apoptosis, which injures their rapid differentiation essential for the
regeneration of hair. Phloroglucinol (PG) is a phenolic compound of Ecklonia
cava, brown algae abundant in Jeju island, Korea. Containing plentiful
polyphenol, PG is known for its instructive effects by inhibiting apoptosis,
scavenging oxygen radicals, and protecting cells against oxidative stress. In
this study, we demonstrate that PG rescues radiosensitive hair follicle stem
cells from gamma radiation-induced apoptosis and DNA damage. To identify
the hair follicle protection capability of PG, we irradiated gamma-rays to the
whole body of C57BL/6 mice at day 6 after depilation with or without PG.
PG or EpiCeram (EC) was applied once at 17.8 hours before irradiation and,
after irradiation, it was applied at 17.8 hours internals until autopsy. At 8
hours after gamma-rays irradiation, PG not only decreased apoptosis which
was suppressed by radiation as shown in control but also decreased
morphlogical changes of hair follicles. Our results suggest that PG presents
radioprotective effects by inhibiting apoptosis of radiosensitive hair follicle stem cells and can PG protects hair follicle stem cells from gamma-ray
induced damage.
목차
Table of contents 1List of tables 2List of figures 3List of abbreviations 4Abstract 5Introduction . 7Materials and methods 10Results 14Discussion . 19References 23Tables . 29Figures 30
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