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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 241 - 247 (7page)
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Sulfated polysaccharide (SP), generally known as fucoidan and commonly found in the cell walls of brown algae, has been reported to present biological effects including anti-inflammatory, anticancer, and antioxidant activities. Exposure to ionizing gamma-ray induces cellular production of reactive oxygen species and hair follicular cells, being the most sensitive to gammaray immediately go through apoptosis and damage their rapid differentiation essential for regeneration of hair. In this study we investigated the protective potential of SP’s against gamma-ray induced hair follicle cells injury. For that, 8.5Gy gamma-ray was irradiated to the whole body of C57BL/6 mouse at day 6 after depilation treated with and without SP. Treatment with SP markedly inhibited formation of thiobarbituric acid-reactive substances(TBARS) compared to control group (without SP) after 48 h of irradiation. Increased cleaved caspase-3 and p53 expression by irradiation was decreased by treatment with SP after 8 h of irradiation. Furthermore, terminal deoxyribonucleotidyl transferase-mediated d-uridine 5' triphosphate nick end labelling (TUNEL) staining showed that the proportion of apoptotic cells in gamma-ray irradiated skins was significantly lower in mouse treated with SP than control group (without SP). Also, SP treatment increased the percentage of Ki-67 positive cells compared with those of irradiation only group. These results suggest that SP has potential as a radioprotector for hair follicular cells.
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참고문헌 (28)
참고문헌 신청
Li, B. / 2008 / Fucoidan: structure and bioactivity / Molecules 13:1671~1695
Chollet, L. / 2016 / Fucoidan in nanomedicine / Mar. Drugs 14:E145
Jiao, G. / 2011 / Chemical structures and bioactivities of sulfated polysaccharides from marine algae / Mar. Drugs 9:196~223
Zaporozhets, T. / 2016 / Prospects for the therapeutic application of sulfated polysaccharides of brown algae in diseases of the cardiovascular system: Review / Pharm. Biol 54:3126~3135
Wang, W. / 2012 / The antiviral activities and mechanisms of marine polysaccharides: An over-view / Mar. Drugs 10:2795~2816
Chollet, L. / 2016 / Fucoidan in nanomedicine / Mar. Drugs 14:E145
Jiao, G. / 2011 / Chemical structures and bioactivities of sulfated polysaccharides from marine algae / Mar. Drugs 9:196~223
Zaporozhets, T. / 2016 / Prospects for the therapeutic application of sulfated polysaccharides of brown algae in diseases of the cardiovascular system: Review / Pharm. Biol 54:3126~3135
Wang, W. / 2012 / The antiviral activities and mechanisms of marine polysaccharides: An over-view / Mar. Drugs 10:2795~2816
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