지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 최태영
- 발행연도
- 2015
- 저작권
- 대구가톨릭대학교 논문은 저작권에 의해 보호받습니다.
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초록· 키워드
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Objectives: To investigate the association between amisulpride-induced hyperprolactinemia and the Taq1A polymorphism in the dopamine receptor D2(DRD2) gene in schizophrenic patients
Methods: The plasma concentrations of prolactin were measured before and after treatment with amisulpride in one hundred and twenty-five schizophrenic patients. The effect of the Taq1A variants of the DRD2 gene on the risk of amisulpride-induced hyperprolactinemia was main the outcome measure. The genotyping for Taq1A(rs1800497) was performed using TaqMan single nucleotide polymorphism(SNP) genotyping assay.
Results: There was a significant difference between baseline prolactin level and prolactin level at 6 weeks of treatment with amisulpride. But no correlations were found between ΔProlactin(prolactin level at 6 weeks minus the baseline prolactin level) and the Taq1A genotypes.
Conclusion: This is the first study to investigate the association between the Taq1A polymorphism and the amisulpride-induced hyperprolactinemia in Korean schizophrenic patients. Futher large-scale researchs on various SNPs in the DRD2 gene will establish clear goals and provide for the unanswered questions described in this study.
Methods: The plasma concentrations of prolactin were measured before and after treatment with amisulpride in one hundred and twenty-five schizophrenic patients. The effect of the Taq1A variants of the DRD2 gene on the risk of amisulpride-induced hyperprolactinemia was main the outcome measure. The genotyping for Taq1A(rs1800497) was performed using TaqMan single nucleotide polymorphism(SNP) genotyping assay.
Results: There was a significant difference between baseline prolactin level and prolactin level at 6 weeks of treatment with amisulpride. But no correlations were found between ΔProlactin(prolactin level at 6 weeks minus the baseline prolactin level) and the Taq1A genotypes.
Conclusion: This is the first study to investigate the association between the Taq1A polymorphism and the amisulpride-induced hyperprolactinemia in Korean schizophrenic patients. Futher large-scale researchs on various SNPs in the DRD2 gene will establish clear goals and provide for the unanswered questions described in this study.
목차
Ⅰ. 서론 1Ⅱ. 방법 41. 연구대상 42. 유전자형분석 43. 약물투여와 프로락틴 혈중농도 54. 통계분석 5Ⅲ. 결과 6Ⅳ.고찰 7References 16
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