지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 219 - 226 (8page)
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Objectives：The aim of this study is to evaluate the association between antipsychotics-induced weight gain and the polymorphisms in the dopamine receptor D2(DRD2) genes.
Methods：We measured the weight and height of 125 schizophrenia patients before and after treatment. The genotyping for rs1800497 was performed using TaqMan single nucleotide polymorphism(SNP) genotyping assay.
Results：There was a significant difference in the amisulpride-induced change of body mass index(BMI) according to the frequency of rs1800497 genotype.
Conclusion：This is the first positive association study between DRD2 gene and the amisulpride induced weight gain in Korean schizophrenia patients. A larger scale research on more SNP of the DRD2 gene will make a progress in the study of amisulpride induced weight gain.
Methods：We measured the weight and height of 125 schizophrenia patients before and after treatment. The genotyping for rs1800497 was performed using TaqMan single nucleotide polymorphism(SNP) genotyping assay.
Results：There was a significant difference in the amisulpride-induced change of body mass index(BMI) according to the frequency of rs1800497 genotype.
Conclusion：This is the first positive association study between DRD2 gene and the amisulpride induced weight gain in Korean schizophrenia patients. A larger scale research on more SNP of the DRD2 gene will make a progress in the study of amisulpride induced weight gain.
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참고문헌
참고문헌 (45)
참고문헌 신청
1. [학술지(정기간행물)] - Allison DB / 1999 / Antipsychotic-induced weight gain : a comprehensive research synthesis / Am J Psychiatry 156 : 1686 ~ 1696
2. [학술지(정기간행물)] - National Institutes of Health / 1998 / Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report / Obes Res 6 (Suppl 2) : 51S ~ 209S
3. [학술지(정기간행물)] - Wirshing DA / 2004 / Schizophrenia and obesity : impact of antipsychotic medications / J Clin Psychiatry 65 (Suppl 18) : 13 ~ 26
4. [학술지(정기간행물)] - Allison DB / 2003 / The impact of weight gain on quality of life among persons with schizophrenia / Psychiatr Serv 54 : 565 ~ 567
5. [학술지(정기간행물)] - Weiden PJ / 2004 / Obesity as a risk factor for antipsychotic noncompliance / Schizophrenia Research 66 : 51 ~ 57
2. [학술지(정기간행물)] - National Institutes of Health / 1998 / Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report / Obes Res 6 (Suppl 2) : 51S ~ 209S
3. [학술지(정기간행물)] - Wirshing DA / 2004 / Schizophrenia and obesity : impact of antipsychotic medications / J Clin Psychiatry 65 (Suppl 18) : 13 ~ 26
4. [학술지(정기간행물)] - Allison DB / 2003 / The impact of weight gain on quality of life among persons with schizophrenia / Psychiatr Serv 54 : 565 ~ 567
5. [학술지(정기간행물)] - Weiden PJ / 2004 / Obesity as a risk factor for antipsychotic noncompliance / Schizophrenia Research 66 : 51 ~ 57
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UCI(KEPA) : I410-ECN-0101-2016-513-001023760