지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 김희택
- 발행연도
- 2013
- 저작권
- 세명대학교 논문은 저작권에 의해 보호받습니다.
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Background and Objectives : Oxidation by active oxygen in the body, and phototoxicity, photoallergic interest has grown, antioxidant and phototoxicity inhibiting substances for research progress. The purpose of this study was to examine the effects on antioxidant and phototoxicity of Rubus coreanus Fruits.
Meterial and Methods : Hs68 cell lines using the DPPH radical scavenging activity, cytotoxic, phototoxic inhibitory activity and apoptosis were measured.
Results :
1. In MTT assay, the concentrations of Rubus coreanus Fruits that were used on the test had no cytotoxicity.
2. In DPPH radical scavenging activity, the concentration of 50 ㎍/㎖, 100 ㎍/㎖ anti-oxidant effect of Rubus coreanus Fruits was statistically significant increased than control group in dose-dependantly.
3. In phototoxic inhibitory activity, Rubus coreanus Fruits dose-dependently increased the cell viability of Hs68 cell lines.
4. The concentration of 50 ㎍/㎖ Rubus coreanus Fruits inhibited the enrichment of nucleus in the Hs68 cell stimulated with UVB.
Conclusions : These results indicate that Rubus coreanus Fruits has anti-oxidant effects and Phototoxic Inhibitory Activity. If further study is performed, the use of Rubus coreanus Fruits will be valuable and beneficial in the therapy of skin aging and damage.
Meterial and Methods : Hs68 cell lines using the DPPH radical scavenging activity, cytotoxic, phototoxic inhibitory activity and apoptosis were measured.
Results :
1. In MTT assay, the concentrations of Rubus coreanus Fruits that were used on the test had no cytotoxicity.
2. In DPPH radical scavenging activity, the concentration of 50 ㎍/㎖, 100 ㎍/㎖ anti-oxidant effect of Rubus coreanus Fruits was statistically significant increased than control group in dose-dependantly.
3. In phototoxic inhibitory activity, Rubus coreanus Fruits dose-dependently increased the cell viability of Hs68 cell lines.
4. The concentration of 50 ㎍/㎖ Rubus coreanus Fruits inhibited the enrichment of nucleus in the Hs68 cell stimulated with UVB.
Conclusions : These results indicate that Rubus coreanus Fruits has anti-oxidant effects and Phototoxic Inhibitory Activity. If further study is performed, the use of Rubus coreanus Fruits will be valuable and beneficial in the therapy of skin aging and damage.
목차
Ⅰ. 서 론 1Ⅱ. 실 험 방 법 31. 실험 재료 31) 시료 준비 32) 세포 배양 33) UVB 광조사 32. 실험방법 41) 세포 독성 42) DPPH radical 소거능 43) Hoechst 염색 54) 통계분석 5Ⅲ. 실 험 성 적 61. 세포 독성 62. DPPH radical 소거능 측정 73. 광독성 억제 활성 측정 84. Apoptosis 측정 9Ⅳ. 고 찰 11Ⅴ. 결 론 15참 고 문 헌 16Abstracts 21
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