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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학위논문
- 저자정보
- 지도교수
- 임성우
- 발행연도
- 2014
- 저작권
- 동국대학교 논문은 저작권에 의해 보호받습니다.
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Objectives : This study was carried out to investigate the inhibitory effect of Banhasasim-tang on early reflux esophagitis by control of gastric peristalsis and lower esophageal sphincter in mice.
Methods : The CON group were mice with no inflammation. The GE group were mice with gastroesophageal reflux elicited by alcohol. The BT group were mice administered Banhasasim-tang after gastroesophageal reflux elicitation. I observed morphological change and production of ghrelin, substance P, iNOS in gastroesophageal junction mucosa. In addition, I examined change of epithelial junction in esophageal mucosa and change of lower esophageal sphincter distribution.
Results : The migration of inflammation-related cells in lamina propria of gastroesophageal junction were decreased in the BT group than the GE group. The positive reaction of ghrelin, substance P, iNOS were significantly decreased in the BT group than the GE group (P<0.05). The injury of epithelial junction in esophageal mucosa and outer oblique layer in lower esophageal sphincter were significantly mitigated by Banhasasim-tang administration in the BT group (P<0.05).
Conclusions : According to the above results, it is supposed that Banhasasim-tang inhibits early reflux esophagitis by control not only gastric peristalsis and acid secretion through ghrelin, substance P but also lower esophageal sphincter through iNOS.
Methods : The CON group were mice with no inflammation. The GE group were mice with gastroesophageal reflux elicited by alcohol. The BT group were mice administered Banhasasim-tang after gastroesophageal reflux elicitation. I observed morphological change and production of ghrelin, substance P, iNOS in gastroesophageal junction mucosa. In addition, I examined change of epithelial junction in esophageal mucosa and change of lower esophageal sphincter distribution.
Results : The migration of inflammation-related cells in lamina propria of gastroesophageal junction were decreased in the BT group than the GE group. The positive reaction of ghrelin, substance P, iNOS were significantly decreased in the BT group than the GE group (P<0.05). The injury of epithelial junction in esophageal mucosa and outer oblique layer in lower esophageal sphincter were significantly mitigated by Banhasasim-tang administration in the BT group (P<0.05).
Conclusions : According to the above results, it is supposed that Banhasasim-tang inhibits early reflux esophagitis by control not only gastric peristalsis and acid secretion through ghrelin, substance P but also lower esophageal sphincter through iNOS.
목차
Ⅰ. 서론 1Ⅱ. 실험 31. 실험 재료 31) 실험 동물 32) 半夏瀉心湯의 제조 32. 실험 방법 51) 역류성 식도염 유발 52) 半夏瀉心湯 투여 53) 조직표본 제작 54) 위식도 연결부 내 위꿈틀운동 인자 변화 관찰 6① Ghrelin 생성 변화 관찰 6② Substance P 생성 변화 관찰 6③ iNOS 생성 변화 관찰 65) 식도 변화 관찰 7① 식도 점막상피의 이음 변화 관찰 7② 하부식도조임근의 분포 변화 관찰 76) 영상 분석과 통계 처리 7Ⅲ. 결과 81. 위식도 연결부 변화 81) 일반적 형태 82) Ghrelin 생성 감소 93) Substance P 생성 감소 104) iNOS 생성 감소 112. 식도 변화 131) 점막상피의 이음 유지 132) 하부식도조임근의 분포 회복 14Ⅳ. 고찰 17Ⅴ. 결론 27참고문헌 28ABSTRACT 36
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