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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 362 - 374 (13page)
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Objectives : This study was carried out to investigate the inhibitory effect of Banhasasim-tang on early reflux esophagitis by control of gastric peristalsis and the lower esophageal sphincter in mice.
Methods : Experimental mice were classified into three groups. The normal group were mice with no inflammation. The control group were mice with gastroesophageal reflux elicited by alcohol. The sample group were mice administered Banhasasim-tang after gastroesophageal reflux elicitation. We observed morphological change and production of ghrelin, substance P, and inducible nitric oxide synthase (iNOS) in gastroesophageal junction mucosa. In addition, we examined change of epithelial junction in esophageal mucosa and change of lower esophageal sphincter distribution.
Results : The migration of inflammation-related cells in lamina propria of gastroesophageal junction decreased more in the sample group than in the control group. The positive reaction of ghrelin, substance P, and iNOS significantly decreased more in the sample group than in the control group (p < 0.05). Injury of the epithelial junction in the esophageal mucosa and outer oblique layer in the lower esophageal sphincter were significantly mitigated by Banhasasim-tang administration in the sample group (p < 0.05).
Conclusions : According to the above results, it is supposed that Banhasasim-tang inhibits early reflux esophagitis by controlling not only gastric peristalsis and acid secretion through ghrelin, and substance P but also the lower esophageal sphincter through iNOS.
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참고문헌 (30)
참고문헌 신청
Biancani P / 1984 / Effects of acute experimental esophagitis on mechanical properties of the lower esophageal sphincter / Gastroenterology 87 (1) : 8 ~ 16
Date Y / 2000 / Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and human
Kim CS / 1982 / An experimental study on the effects of substance P on gastric secretion in rats / Korean J Gastroenterol 14 (2) : 13 ~ 16
Kuroiwa Y / 2008 / Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
Lecci A / 1997 / Role of tachykinin NK1 and NK2 receptors on colonic motility in anesthetized rat: effect of agonists / Can J Physiol Pharmacol 75 (6) : 582 ~ 586
Date Y / 2000 / Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and human
Kim CS / 1982 / An experimental study on the effects of substance P on gastric secretion in rats / Korean J Gastroenterol 14 (2) : 13 ~ 16
Kuroiwa Y / 2008 / Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
Lecci A / 1997 / Role of tachykinin NK1 and NK2 receptors on colonic motility in anesthetized rat: effect of agonists / Can J Physiol Pharmacol 75 (6) : 582 ~ 586
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