This study investigates the relationship between women’s makeup behavior and Flourish, and this study confirms the double mediation effect of self-esteem and self-efficacy in the effect of makeup behavior on Flourish. The study aims to provide a new perspective on women’s makeup behavior and Flourish, confirm the double mediation effect of self-esteem and self-efficacy, which has been insufficient in previous studies, and provide essential data that can be utilized in future research and beauty-related fields. The study subjects were women aged 20 to 50 nationwide. An online survey was conducted, and a final 249 copies were used for analysis. SPSS 28.0 and Amos 29.0 programs were used for data analysis, and the significance of the mediation effect was verified through frequency analysis, validity and reliability analysis, correlation analysis, structural equation modeling analysis, and bootstrapping analysis. The findings of the study are as follows. First, makeup behavior was positively correlated with self-esteem, self-efficacy, and Flourish. Self-esteem was positively correlated with self-efficacy and Flourish. Self-efficacy was positively correlated with Flourish. Second, women’s makeup behavior affected self-esteem, and self-esteem affected self-efficacy and Flourish. Self-efficacy was also confirmed to affect Flourish. Third, the results of examining the mediating effect of self-esteem and self-efficacy in the relationship between makeup behavior and Flourish showed that makeup behavior affected Flourish through self-esteem, and there was a sequential mediating effect of self-esteem and self-efficacy in the relationship between makeup behavior and Flourish. As a result, although makeup behavior did not directly affect Flourish in the relationship between women’s makeup behavior and Flourish, a significant correlation was confirmed, suggesting the possibility that makeup behavior may indirectly affect women’s happiness and well-being. As a result, while women’s makeup behavior did not have a direct effect on Flourish, a significant correlation was identified. This finding suggests the possibility that makeup behavior may indirectly influence women’s happiness and well-being. Furthermore, the results show that the more women direct their makeup behavior to express the impression and image they seek, the more they can increase their positive emotions and happiness.