지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2025.3
- 수록면
- 87 - 96 (10page)
이용수
초록· 키워드
오류제보하기
Importance: Porcine circovirus type 2 (PCV2) is a major pathogen responsible for the porcine circovirus-associated disease, causing significant economic losses in the swine industry worldwide. PCV2d has become the dominant, following a sequential shift from the previously predominant PCV2a and PCV2b genotypes. Although an effective vaccine based on virus-like particles (VLPs) of recombinant PCV2d-based capsid protein has been developed, intramuscular inoculation of the vaccine still induces a wide variety of side effects. In contrast, intradermal vaccination offers benefits, including enhanced immune activation due to the abundance of dendritic cells in the dermal layer, while also reducing side effects.
Objective: Developing a novel vaccine combined with a needle-free inoculation technique is required to elicit protection against PCV2d infection with fewer side effects and higher effectiveness. This study aimed to develop a VLP-based vaccine targeting PCV2d and assess its efficacy when administered intradermally using a needle-free system.
Methods: To optimize the intradermal vaccine formulation, we evaluated humoral immunity and neutralizing activity following intradermal administration of test vaccines prepared with varying adjuvant types, adjuvant ratios, and antigen doses.
Results: IMS1313 adjuvant provided the best induction of total IgG and neutralizing antibody titers. A dose-dependent evaluation indicated that 20 μg of antigen combined with 40% IMS1313 achieved optimal immune responses. Compared to intramuscular injection, intradermal injection using this formulation induced 1.3-fold higher neutralizing antibody titers, demonstrating higher efficacy.
Conclusions and Relevance: Intradermal vaccination using a PCV2d VLP-based vaccine improves immunogenicity and cost-effectiveness, providing a promising strategy for controlling PCV2d infections in swine.
Objective: Developing a novel vaccine combined with a needle-free inoculation technique is required to elicit protection against PCV2d infection with fewer side effects and higher effectiveness. This study aimed to develop a VLP-based vaccine targeting PCV2d and assess its efficacy when administered intradermally using a needle-free system.
Methods: To optimize the intradermal vaccine formulation, we evaluated humoral immunity and neutralizing activity following intradermal administration of test vaccines prepared with varying adjuvant types, adjuvant ratios, and antigen doses.
Results: IMS1313 adjuvant provided the best induction of total IgG and neutralizing antibody titers. A dose-dependent evaluation indicated that 20 μg of antigen combined with 40% IMS1313 achieved optimal immune responses. Compared to intramuscular injection, intradermal injection using this formulation induced 1.3-fold higher neutralizing antibody titers, demonstrating higher efficacy.
Conclusions and Relevance: Intradermal vaccination using a PCV2d VLP-based vaccine improves immunogenicity and cost-effectiveness, providing a promising strategy for controlling PCV2d infections in swine.
목차
ABSTRACT
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Assessing PCV2 antibodies in field pigs vaccinated with different porcine circovirus 2 vaccines using two commercial ELISA systems
Journal of Veterinary Science
2015 .03
-
Molecular epidemiological surveillance and complete genome analysis of porcine circoviruses in wild boars (Sus scrofa) in Gyeongnam Province, South Korea
Journal of Veterinary Science
2024 .11
-
Changes in Serotype of Streptococcus pneumoniae After the Introduction of the 13-Valent Pneumococcal Vaccine in a Homogenous Population on Jeju Island
Infection and Chemotherapy
2019 .01
-
제주지역의 돼지 써코바이러스 2형 관련 장염에 대한 병리학적 특징
Korean Journal of Veterinary Research(대한수의학회지)
2020 .09
-
The changes of immune-related molecules within the ileal mucosa of piglets infected with porcine circovirus type 2
Journal of Veterinary Science
2020 .09
-
Early Changes in the Serotype Distribution of Invasive Pneumococcal Isolates from Children after the Introduction of Extended-valent Pneumococcal Conjugate Vaccines in Korea, 2011-2013
Journal of Korean Medical Science
2016 .01
-
Use of a multinomial logistic regression model to evaluate risk factors for porcine circovirus type 2 infection on pig farms in the Republic of Korea
예방수의학회지
2017 .09
-
경북지역 양돈장의 돼지생식기호흡기증후군, 돼지써코바이러스-2 항체가 조사
한국가축위생학회지
2015 .01
-
Porcine circovirus type 2 increases interleukin-1beta and interleukin-10 production via the MyD88-NF-kappa B signaling pathway in porcine alveolar macrophages
Journal of Veterinary Science
2017 .06
-
폐렴사슬알균 예방접종의 최신 지견
Korean Journal of Family Practice
2024 .09
-
Recent Advances of Vaccine Adjuvants for Infectious Diseases
Immune Network
2015 .04
-
Needleless intradermal vaccination for foot-and-mouth disease induced granuloma-free effective protection in pigs
Journal of Veterinary Science
2019 .05
-
Duplex nested reverse transcriptase polymerase chain reaction for simultaneous detection of type 2 porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 from tissue samples
Journal of Veterinary Science
2017 .06
-
Recent vaccine technology in industrial animals
Clinical and Experimental Vaccine Research
2016 .01
-
Changes in the Serotype Distribution among Antibiotic Resistant Carriage Streptococcus pneumoniae Isolates in Children after the Introduction of the Extended-Valency Pneumococcal Conjugate Vaccine
Journal of Korean Medical Science
2017 .01
-
Review of COVID-19 Vaccines and Their Evidence in Older Adults
Annals of geriatric medicine and research
2021 .01
-
Occult bacteremia in children with simple febrile seizure in the post-pneumococcal conjugate vaccine era
대한소아응급의학회지
2021 .12
-
Indirect Effects of Pneumococcal Conjugate Vaccines in National Immunization Programs for Children on Adult Pneumococcal Disease
Infection and Chemotherapy
2016 .12
-
Should the COVID-19 Vaccine be Administered Simultaneously with Other Vaccines?
Infection and Chemotherapy
2021 .09
이 논문의 저자 정보
이 논문과 함께 이용한 논문
Tissue-Specific Metabolic Reprogramming in Innate Lymphoid Cells and Its Impact on Disease
Jongho Ham
,
Wooseok Yang
,
Hye Young Kim
Immune Network
2025
.02
Safety and effectiveness of direct oral anticoagulants in fragile patients with venous thromboembolism: a retrospective cohort observational study
Hojong Pa
,
k
,
Sang Jun Pa
외 2명
Annals of Surgical Treatment and Research
2025
.03
Impact of self-efficacy–based health education programs on behavior modification for Opisthorchis viverrini and cholangiocarcinoma prevention in Thailand: A systematic review and meta-analysis
Wo
,
athon Busabong
,
Somkiattiyos Wo
외 4명
Parasites, Hosts and Diseases
2025
.02
Development of the Korean Quality Improvement Platform in Surgery (K-QIPS) program: a nationwide project to improve surgical quality and patient safety
Jeong-Moo Lee
,
In Woong Han
,
Oh Chul Kwon
외 18명
Annals of Surgical Treatment and Research
2024
.12
Comparative Analysis of Lipid Nanoparticle and Lipoplex Stability for Efficient mRNA Vaccine Delivery and Long-Term Storage
Ukhyun LEE
,
Sangmim LEE
,
Hyunjin KIM
외 1명
한국생물공학회 학술대회
2024
.09
최근 본 자료
댓글(0)
0