지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2025.2
- 수록면
- 79 - 85 (7page)
- DOI
- 10.5322/JESI.2025.34.2.79
이용수
초록· 키워드
오류제보하기
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rigidity, tremors, and postural instability, primarily caused by the degeneration of dopaminergic neurons in the substantia nigra. While current treatments focus on managing motor symptoms, non-motor symptoms, including sleep disturbances, are increasingly being recognized as significant contributors to reduced quality of life in patients with PD. Melatonin, a key hormone in regulating circadian rhythms, is often dysregulated in PD, exacerbating insomnia and other sleep disorders. This study investigated the potential role of 20-hydroxyecdysone, an insect-molting hormone, in alleviating sleep disturbances associated with PD. Using STRING database analysis , we identified 12 melatonin-related genes, and confirmed significant downregulation of Mtnr1a in the hypothalamus of 1-Methyl-4-(2′-methylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride-induced PD mouse models. Functional assays demonstrated that 20-hydroxyecdysones enhanced melatonin receptor binding affinity (IC₅₀: 5.29 μM) and improved sleep onset and duration in alfaxan-induced sleep tests. Furthermore, the expression of the cellular oncogene fos, a biomarker for neuronal activation, was significantly elevated in the ventrolateral preoptic nucleus, suggesting 20-hydroxyecdysone’s role in activating sleep-regulating neural circuits. These findings highlight the therapeutic potential of 20-hydroxyecdysone in improving PD-related sleep disturbances by modulating melatonin receptor activity, and warrant further investigation into its molecular mechanisms.
목차
Abstract
1. 서론
2. 재료 및 방법
3. 결과 및 고찰
4. 결론
REFERENCES
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