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자료유형
학술저널
저자정보
Hye-Jin Lee (Inje University) Young-Min Park (Inje University College of Medicine) Miseon Shim (Tech University of Korea)
저널정보
대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience Vol.22 No.3
발행연도
2024.8
수록면
451 - 457 (7page)
DOI
10.9758/cpn.23.1133

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초록· 키워드

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Objective: Nonsuicidal self-injury (NSSI), which involves deliberate harm to body tissues without suicidal intent, repre sents an escalating clinical concern. We used electroencephalography (EEG) to investigate the differences in functional connectivity (FC) patterns in patients with depression with and without a history of NSSI. Methods: Seventy-seven patients with mood disorders experiencing major depressive episodes were categorized into NSSI (Group A; n = 31) and non-NSSI (Group B; n = 46) groups on the basis of their NSSI history. EEG data were collected and FC was analyzed using coherence (Coh), imaginary coherence (iCoh), and phase-locking value (PLV) metrics. Network indices based on graph theory were calculated. Demographic and clinical characteristics and scale scores were compared between groups A and B. Results: While the two groups showed no significant differences in demographic characteristics such as age and diag nosis, the Beck Depression Inventory and Suicidal Ideation Questionnaire (SIQ) scores were higher in Group A. Binary logistic regression analyses revealed associations of NSSI with sex and the SIQ score. We examined the connectivity of 1,326 pairs of signals across six frequency bands, yielding 7,956 signal pairs. The two groups showed no significant differences in the Coh, iCoh, corrected PLV, or network indices but showed significant differences in all the frequency bands when an uncorrected t test was used. Conclusion: In this study, FC differences in depression with and without NSSI were not observed. Further well-controlled research is expected to clarify neurobiological underpinnings and guide future interventions.

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