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논문 기본 정보

자료유형
학술저널
저자정보
Lazara Alacán Pérez (¨Manuel Fajardo¨ Hospital, Havana, Cuba) Julio César Fernández Travieso (National Centre for Scientific Research, Havana, Cuba) Evelyn Anie González Pla (National Centre for Scientific Research, Havana, Cuba) Yeni González Liriano (¨Manuel Fajardo¨ Hospital, Havana, Cuba) Olaine Regla Gray Lovio (¨Manuel Fajardo¨ Hospital, Havana, Cuba) Elizabeth Sanler Wong (National Institute of Oncology and Radiobiology, Havana, Cuba) Maylen Rodríguez Ordaz (¨Carlos Juan Finlay¨ Hospital, Havana, Cuba) Yanela Rodríguez Lorenzo (¨Carlos Juan Finlay¨ Hospital, Havana, Cuba) Marlenys Pérez Bruzón (¨Carlos Juan Finlay¨ Hospital, Havana, Cuba) Jose Alejandro Díaz Cardoso (¨Carlos Juan Finlay¨ Hospital, Havana, Cuba) Ada Bermudez Sori (¨Carlos Juan Finlay¨ Hospital, Havana, Cuba) Juana del Valle Rodríguez (¨Manuel Fajardo¨ Hospital, Havana, Cuba) Elvia Nelemi Santos González (¨Carlos Juan Finlay¨ Hospital, Havana, Cuba) Lisandra Linares Luna (¨Carlos Juan Finlay¨ Hospital, Havana, Cuba) Ana Labrada Carballo (National Centre for Scientific Research, Havana, Cuba) Yenney Reyes Nuñez (National Centre for Scientific Research, Havana, Cuba) Yanay Fernández Domínguez (National Centre for Scientific Research, Havana, Cuba) Manuel Eduardo Cordero Hernández (National Centre for Scientific Research, Havana, Cuba) Sarahí Mendoza Castaño (National Centre for Scientific Research, Havana, Cuba) Gladys Jiménez Rivero (National Clinical Trials Coordinators Centre, Havana, Cuba) Marta Lidia Barrera Moreira (National Clinical Trials Coordinators Centre, Havana, Cuba) Rolando Uranga Piña (National Clinical Trials Coordinators Centre, Havana, Cuba)
저널정보
대한의진균학회 대한의진균학회지 Journal of Mycology and Infection Vol.29 No.3
발행연도
2024.9
수록면
98 - 107 (10page)

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Background: Dermatophytosis are the leading cause of fungal infections worldwide. Objective: To compare the efficacy and safety of ozonated sunflower oil versus ketoconazole and terbinafine in patients with dermatophytosis. Methods: Multicenter Phase III study, it had an open, randomized, comparative design, with three parallel group to which ozonated sunflower oil was apply, or ketoconazole, or terbinafine, twice a day for 6 weeks. The effect on the clinical and mycological cure rate was prefix as the primary efficacy variable. The effect on treatment time to achieve cure was consider as a secondary efficacy variable. All data were analyzed by the intention-to-treat method. Results: The study included 300 patients of both sexes with a diagnosis of dermatophytosis, who were randomly distributed into three groups that received ozonated sunflower oil, or ketoconazole, or terbinafine, respectively. Treatment with ozonated sunflower oil produced a total clinical and mycological cure rate in 78% of patients, similar to ketoconazole (78%) and terbinafine (77%) treatment. Complete mycological cure was achieved in 87% of patients treated with ozonated sunflower oil, similar to ketoconazole (88%) and terbinafine (89%) treatments. Regarding the healing time, of the 233 patients with complete clinical cure, 10 patients (4.3%) were completely cure after 2 weeks of treatment, 58 patients (24.9%) after 4 weeks and 164 patients (70.4%) after 6 weeks. The treatments were safe and well tolerated. Conclusions: It's concluded that ozonated sunflower oil applied for six weeks showed comparable efficacy and safety with ketoconazole and terbinafine in patients with dermatophytosis.
#Dermatophytes #Ketoconazole #Ozonated sunflower oil #Terbinafine #Tinea pedis

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