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논문 기본 정보

자료유형
학술저널
저자정보
Chenlian Quan (1 Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China) Zhong Zheng (Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China) Siyu Cao (Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China) Yong Wu (Fudan University Shanghai Cancer Center) Wei Zhang (Fudan University) Yan Huang (Fudan University Shanghai Cancer Center, Shanghai, China)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.35 No.4
발행연도
2024.7
수록면
1 - 12 (12page)
DOI
https://doi.org/10.3802/jgo.2024.35.e98

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Objective: As an indolent malignant tumor, the long-term management of low-gradeendometrial stromal sarcoma (LGESS) patients required awareness, especially themanagement of recurrences. Unfortunately, few studies focused on the treatment ofrecurrent LGESS. Our study aimed to investigate the prognostic factors and the value ofrecurrent surger y on recurrent LGESS. Methods: This retrospective study consecutively recruited patients with pathologicallydiagnosed recurrent LGESS at our center from April 1, 2004 to April 1, 2020. Results: After a median follow-up of 137.0 months (95% confidence inter val=85.4–188.6),the 5-year cumulative sur vival rate of the cohort of 38 patients with recurrent LGESS was71.1%. The median overall sur vival (OS) and post-recurrence sur vival (PRS) was 156 and89.0 months. Sur vival analysis showed that patients with younger age, positive estrogenreceptor (ER) and optimal abdominopelvic debulking in the first recurrent surger y had betterprognosis (p<0.05). Multivariate analysis showed that optimal abdominopelvic debulkingin the first recurrent surger y was the only independent prognostic factor for OS and PRS(OS=216.0/35.0 months, hazard ratio [HR]=5.319, p=0.034; PRS=not reached/4.0 months,HR=10.900, p=0.006). There was no significant difference in OS and PRS between patientsrecurred only once and those recurred at least twice (p>0.05). Conclusions: The prognosis of recurrent LGESS was favorable. Optimal debulking of noresidual tumor in abdominal and pelvic cavity should be the first choice of treatment forrecurrent patients, while preser vation of ovar y or fertility should not be recommended.

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