Prognostic Factors, Treatment and Outcome in a Turkish Population with Endometrial Stromal Sarcoma

Donertas, Ayla; Nayki, Umit; Nayki, Cenk; Ulug, Pasa; Gultekin, Emre; Yildirim, Yusuf

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자료유형: 학술저널

저자정보: Donertas, Ayla (Department Obstetrics and Gynaecology, Tepecik Training and Research Hospital) Nayki, Umit (Department Obstetrics and Gynaecology, Erzincan University, Medical Faculty) Nayki, Cenk (Department Obstetrics and Gynaecology, Erzincan University, Medical Faculty) Ulug, Pasa (Department Obstetrics and Gynaecology, Erzincan University, Medical Faculty) Gultekin, Emre (Department Obstetrics and Gynaecology, Tepecik Training and Research Hospital) Yildirim, Yusuf (Department Obstetrics and Gynaecology, Tepecik Training and Research Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제3호

발행연도: 2015.1

수록면: 881 - 887 (7page)

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Purpose: To analyze treatment modalities and prognostic factors in patients with Stage I-II endometrial stromal sarcoma (ESS). Materials and Methods: Twenty four patients (nineteen with low-grade ESS [LGESS] and five with high-grade ESS [HGESS]) were assessed retrospectively in terms of general characteristics, prognostic factors, treatment methods and survival. Results: Twenty patients were at Stage I and three were at Stage II. The stage of one patient could not be determined. With respect to age and comorbidity, no statistically significant difference was found among disease-free survival (DFS) (p=0.990; p=0.995). However, DFS was significantly shorter in Stage II than Stage I patients (p=0.002). It was also significantly shorter in HGESS patients than in LGESS patients (p=0.000). There was no statistically significant differences among the overall survival (OVS) times of patients with respect to age at diagnosis and comorbid disease (p=0.905; p=0.979) but OVS was significantly shorter in patients with HGESS (p=0.00) and Stage II disease (p=0.001). No statistically significant difference was found with respect to OVS between patients who received radiotherapy (RT) and those who did not receive RT (p=0.055). It was not statistically possible to include other treatment modalities in the analysis because of the small sample size. Conclusions: Grade and stage of a tumour were found to be the most important prognostic factors. It was not possible to determine the optimal surgical method and the effect of adjuvant treatment since the number of cases was insufficient.

#Endometrial stromal sarcoma #prognostic factors #treatment methods

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