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논문 기본 정보

자료유형
학술저널
저자정보
Hyun Ji Kim (Korea University College of Medicine) Bo Hye Kim (Seoul National University College of Medicine) Dong-Kyu Kim (Seoul National University College of Medicine) Hanbin Kim (Seoul National University College of Medicine) Sang-Hyun Choi (Korea University College of Medicine) Dong-Hoon Kim (Korea University College of Medicine) Myunghwan Choi (Seoul National University) Inhee Mook-Jung (Seoul National University College of Medicine) Yong Taek Jeong (Korea University College of Medicine) Obin Kwon (Seoul National University College of Medicine)
저널정보
한국뇌신경과학회 Experimental Neurobiology Experimental Neurobiology Vol.33 No.4
발행연도
2024.8
수록면
202 - 214 (13page)

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Numerous systemic diseases manifest with oral symptoms and signs. The molecular diagnosis of Alzheimer’s disease (AD), the most prevalent neurodegenerative disease worldwide, currently relies on invasive or expensive methods, emphasizing the imperative for easily accessible biomarkers. In this study, we explored the expression patterns of key proteins implicated in AD pathophysiology within the taste buds of mice. We detected the expression of amyloid precursor protein (APP) and tau protein in the taste buds of normal C57BL/6 mice. Phosphorylated tau was predominantly found in type II and III taste cells, while APP was located in type I taste cells. Remarkably, we observed significantly stronger immunoreactivity to phosphorylated tau in the taste buds of aged AD mouse models compared to age-matched controls. These findings underscore the oral expression of biomarkers associated with AD, highlighting the diagnostic potential of the oral cavity for neurodegenerative diseases.

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