지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.9
- 수록면
- 101 - 107 (7page)
- DOI
- 10.1016/j.afos.2024.08.001
이용수
초록· 키워드
오류제보하기
Objectives: We examined the effects of whole-body vibration (WBV) on bone properties in type 2 diabetes (T2DM) model rats.
Methods: Twenty male Hos:ZFDM-Leprfa, fa/fa rats (divided into DM and WBV groups, N = 10 each) and 10 Hos: ZFDM-Leprfa, fa/+ rats (as the control (CON) group) were used. The WBV group underwent WBV at 45 Hz frequency, with 0.5 g acceleration (15 min/day, 5 days/week) for 8 weeks. Trabecular and cortical bone mass, trabecular bone microstructure (TBMS), and cortical bone geometry (CBG) were analyzed via micro-computed tomography. Bone mechanical strength (maximum load, break point, and stiffness) was also measured. Additionally, bone metabolic and DM-related markers were determined.
Results: The bone mechanical strength of the femur improved in the WBV group, although muscle atrophy and bone deterioration were observed in the DM and WBV groups. The serum levels of bone-specific alkaline phosphatase and tartrate-resistant acid phosphatase-5b were significantly higher in the DM and WBV groups than in the CON group. Serum glucose and blood urea nitrogen levels were significantly lower in the WBV group than in the DM group.
Conclusions: This study suggests that WBV potentially improves the decrease in the bone mechanical strength of the femur, although it does not prevent the deterioration of bone mineral content, TBMS, and CBG parameters.
Further studies are needed to investigate the effective timing and duration of WBV and the conditions that prevent T2DM and deterioration of bone properties and clarify the mechanism underlying WBV effects on bone properties in DM animals.
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