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논문 기본 정보

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학술저널
저자정보
Seogsong Jeong (Department of Biomedical Informatics, Korea University College of Medicine, Seoul; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul) Yun Hwan Oh (Department of Family Medicine, College of Medicine, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, Korea) Joseph C Ahn (Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA) Seulggie Choi (Department of Internal Medicine, Seoul National University Hospital, Seoul) Sun Jae Park (Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul) Hye Jun Kim (Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul) Gyeongsil Lee (Department of Family Medicine, Life Clinic, Seoul) Joung Sik Son (Department of Internal Medicine, Hanyang University Hospital, Seoul) Heejoon Jang (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea) Dong Hyeon Lee (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea) Meng Sha (Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai) Lei Chen (The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Shanghai; National Center for Liver Cancer, Shanghai, China) Won Kim (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul; Department of Internal Me) Sang Min Park (Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul; Department of Family Medicine, Life Clinic, Seoul)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology Vol.30 No.3
발행연도
2024.7
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487 - 499 (13page)

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Background/Aims: To determine the association between evolutionary changes in metabolic dysfunctionassociated steatotic liver disease (MASLD) status and the risk of hepatocellular carcinoma (HCC) in a nationwide population-based cohort. Methods: Information on study participants was derived from the Korea National Health Insurance Service database. The study population consisted of 5,080,410 participants who underwent two consecutive biennial health screenings between 2009 and 2012. All participants were followed up until HCC, death, or 31 December 2020. The association of evolutionary changes in MASLD status, as assessed by the fatty liver index and cardiometabolic risk factors, including persistent non-MASLD, resolved MASLD, incident MASLD, and persistent MASLD, with HCC risk was evaluated using multivariable-adjusted Cox proportional hazards regression. Results: Among the 5,080,410 participants with 39,910,331 person-years of follow-up, 4,801 participants developed HCC. The incidence of HCC in participants with resolved, incident, and persistent MASLD was approximately 2.2-, 2.3-, and 4.7-fold higher, respectively, than that in those with persistent non-MASLD among the Korean adult population. When stratifying the participants according to the evolutionary change in MASLD status, persistent (adjusted hazard ratio [aHR], 2.94; 95% confidence interval [CI], 2.68–3.21; P<0.001), incident (aHR, 1.85; 95% CI, 1.63–2.10; P<0.001), and resolved MASLD (aHR, 1.33; 95% CI, 1.18–1.50; P<0.001) had an increased risk of HCC compared to persistent non-MASLD. Conclusions: The evolutionary changes in MASLD were associated with the differential risk of HCC independent of metabolic risk factors and concomitant medications, providing additional information on the risk of HCC stratification in patients with MASLD.
#Liver neoplasms #Fatty liver #Epidemiology #Cohort studies

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