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논문 기본 정보

자료유형
학술저널
저자정보
Michihiro Iwaki (Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan) Hideki Fujii (Department of Hepatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan) Hideki Hayashi (Department of Gastroenterology and Hepatology, Gifu Municipal Hospital, Gifu, Japan) Hidenori Toyoda (Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan) Satoshi Oeda (Liver Center and Department of Laboratory Medicine, Saga University Hospital, Saga, Japan) Hideyuki Hyogo (Hyogo Life Care Clinic Hiroshima, Hiroshima, Japan) Miwa Kawanaka (Department of General Internal Medicine2, Kawasaki Medical Center, Kawasaki Medical School, Okayama, Japan) Asahiro Morishita (Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan) Kensuke Munekage (Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan; Department of Gastroenterology, Kochi Prefectural Hata Kenmin Hospital, Kochi, Japan) Kazuhito Kawata (Hepatology Division, Department of Internal Medicine II, Hamamatsu University School of Medicine, Shizuoka, Japan) Tsubasa Tsutsumi (Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan) Koji Sawada (Division of Metabolism and Biosystemic Science, Gastroenterology, and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan) Tatsuji Maeshiro (Department of Gastroenterology, Urasoe General Hospital, Okinawa, Japan) Hiroshi Tobita (Department of Hepatology, Shimane University Hospital, Shimane, Japan) Yuichi Yoshida (Department of Gastroenterology and Hepatology, Suita Municipal Hospital, Osaka, Japan) Masafumi Naito (Department of Gastroenterology and Hepatology, Suita Municipal Hospital, Osaka, Japan) Asuka Araki (Division of Pathology, Shimane University Hospital, Shimane, Japan) Shingo Arakaki (Department of Gastroenterology, Urasoe General Hospital, Okinawa, Japan) Takumi Kawaguchi (Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan) Hidenao Noritake (Hepatology Division, Department of Internal Medicine II, Hamamatsu University School of Medicine, Shizuoka, Japan) Masafumi Ono (Division of Innovative Medicine for Hepatobiliary & Pancreatology, Faculty of Medicine, Kagawa University, Kagawa, Japan) Tsutomu Masaki (Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan) Satoshi Yasuda (Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Japan) Eiichi Tomita (Department of Gastroenterology and Hepatology, Gifu Municipal Hospital, Gifu, Japan) Masato Yoneda (Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan) Akihiro Tokushige (Department of Clinical Pharmacology and Therapeutics School of Medicine University of the Ryukyus, Okinawa, Japan) Yoshihiro Kamada (Department of Advanced Metabolic Hepatology, Osaka University, Graduate School of Medicine, Osaka, Japan) Hirokazu Takahashi (Liver Center, Saga University Hospital, Saga, Japan) Shinichiro Ueda (Department of Clinical Pharmacology and Therapeutics School of Medicine University of the Ryukyus, Okinawa, Japan) Shinichi Aishima (Department of Scientific Pathology Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan) Atsushi Nakajima (Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan) Takeshi Okanoue (Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Suita, Japan)
저널정보
대한간학회 Clinical and Molecular Hepatology Clinical and Molecular Hepatology Vol.30 No.2
발행연도
2024.4
수록면
225 - 234 (10page)

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Background/Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) was recently proposed as an alternative disease concept to nonalcoholic fatty liver disease (NAFLD). We aimed to investigate the prognosis of patients with biopsy-confirmed MASLD using data from a multicenter study. Methods: This was a sub-analysis of the Clinical Outcome Nonalcoholic Fatty Liver Disease (CLIONE) study that included 1,398 patients with NAFLD. Liver biopsy specimens were pathologically diagnosed and histologically scored using the NASH Clinical Research Network system, the FLIP algorithm, and the SAF score. Patients who met at least one cardiometabolic criterion were diagnosed with MASLD. Results: Approximately 99% of cases (n=1,381) were classified as MASLD. Patients with no cardiometabolic risk (n=17) had a significantly lower BMI than patients with MASLD (20.9 kg/m2 vs. 28.0 kg/m2, P<0.001), in addition to significantly lower levels of inflammation, ballooning, NAFLD activity score, and fibrosis stage based on liver histology. These 17 patients had a median follow-up of 5.9 years, equivalent to 115 person-years, with no deaths, liver-related events, cardiovascular events, or extrahepatic cancers. The results showed that the prognosis for pure MASLD was similar to that for the original CLIONE cohort, with 47 deaths and one patient who underwent orthotopic liver transplantation. The leading cause of death was extrahepatic cancer (n=10), while the leading causes of liver-related death were liver failure (n=9), hepatocellular carcinoma (n=8), and cholangiocarcinoma (n=4). Conclusions: Approximately 99% of NAFLD cases were considered MASLD based on the 2023 liver disease nomenclature. The NAFLD-only group, which is not encompassed by MASLD, had a relatively mild histopathologic severity and a favorable prognosis. Consequently, the prognosis of MASLD is similar to that previously reported for NAFLD.
#Prognosis #Steatotic liver disease #Liver biopsy

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