지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제28권 제4호
- 발행연도
- 2024.7
- 수록면
- 345 - 359 (15page)
- DOI
- 10.4196/kjpp.2024.28.4.345
이용수
초록· 키워드
오류제보하기
Deposition of extracellular matrix (ECM) in the trabecular meshwork (TM) increases aqueous humour outflow resistance leading to elevation of intraocular pressure (IOP) in primary open-angle glaucoma, which remains the only modifiable risk factor. Resveratrol has been shown to counteract the steroid-induced increase in IOP and increase the TM expression of ECM proteolytic enzymes; however, its effects on the deposition of ECM components by TM and its associated pathways, such as TGF-β-SMAD signalling remain uncertain. This study, therefore, explored the effects of trans-resveratrol on the expression of ECM components, SMAD signalling molecules, plasminogen activator inhibitor-1 and tissue plasminogen activator in dexamethasone-treated human TM cells (HTMCs). We also studied the nature of molecular interaction of trans -resveratrol with SMAD4 domains using ensemble docking. Treatment of HTMCs with 12.5 µM trans-resveratrol downregulated the dexamethasone-induced increase in collagen, fibronectin and α-smooth muscle actin at gene and protein levels through downregulation of TGF-β1, SMAD4, and upregulation of SMAD7. Downregulation of TGF-β1 signalling by trans-resveratrol could be attributed to its effect on the transcriptional activity due to high affinity for the MH2 domain of SMAD4. These effects may contribute to resveratrol's IOP-lowering properties by reducing ECM deposition and enhancing aqueous humour outflow in the TM.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A study on the mechanism of resistance to non-small cell lung cancer therapeutic application using mouse orthotopic model
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Clinicopathological Significance of SMAD4 Expression in Breast Cancer
Journal of Breast Disease
2019 .01
-
Copper oxide nanoparticles induce a fibrotic response via TGF-β1/Smad3 signaling in human airway epithelial cells
한국실험동물학회 학술발표대회 논문집
2018 .01
-
Copper oxide nanoparticles induce a fibrotic response via TGF-β1/Smad3 signaling in human airway epithelial cells
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Hypoxia-Inducible Factor 1α Regulates the Transforming Growth Factor β1/ SMAD Family Member 3 Pathway to Promote Breast Cancer Progression
Journal of Breast Cancer
2018 .01
-
Hypoxia-Inducible Factor 1α Regulates the Transforming Growth Factor β1/ SMAD Family Member 3 Pathway to Promote Breast Cancer Progression
Journal of Breast Cancer
2018 .01
-
Clinicopathological Characterization and Prognostic Implication of SMAD4 Expression in Colorectal Carcinoma
Journal of Pathology and Translational Medicine
2019 .01
-
Aspirin-Triggered Resolvin D1 Inhibits TGF-β1-Induced EndMT through Increasing the Expression of Smad7 and Is Closely Related to Oxidative Stress
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Smad3 deficiency accelerates tongue wound healing via epithelial cell-extracellular matrix interactions
Oral Biology Research
2022 .12
-
Signaling web of SMADs and STAT3 in the development of arthritogenic Th17
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Dendritic cell specific targeting of Smad2 enhances anti-tumor immunity
한국실험동물학회 학술발표대회 논문집
2019 .07
-
음양곽(淫羊藿) 열수 추출물의 Smad 신호 억제를 통한 간성상세포의 활성 조절
대한한의학방제학회지
2018 .01
-
The Effects of Retinoic Acid and MAPK Inhibitors on Phosphorylation of Smad2/3 Induced by Transforming Growth Factor β1
Tuberculosis and Respiratory Diseases
2019 .01
-
Identification of Epithelial-Mesenchymal Transition-related Target Genes Induced by the Mutation of Smad3 Linker Phosphorylation
대한암예방학회지
2018 .01
-
Melatonin suppresses fibrotic responses induced by cigarette smoke via TGF-β1/Smad signaling
한국실험동물학회 학술발표대회 논문집
2015 .08
-
Aloe vera prevents lung fibrosis by suppressing TGF-β/Smad pathway
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Inhibitory effects of resveratrol on hepatitis B virus X protein-induced hepatocellular carcinoma
Journal of Veterinary Science
2017 .12
-
Smad1 Expression in Follicular Lymphoma
Journal of Pathology and Translational Medicine
2015 .01
-
Effects of Trabecular Meshwork Width and Schlemm’s Canal Area on Intraocular Pressure Reduction in Glaucoma Patients
Korean Journal of Ophthalmology
2021 .01
-
Pharbitis nil extracts ameliorate high fat diet-induced liver fibrosis through regulating TGFβ1-Smad2/3 pathway
한국실험동물학회 학술발표대회 논문집
2020 .07
최근 본 자료
댓글(0)
0