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논문 기본 정보

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학술저널
저자정보
Wang Ying (School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong Provincial Key Laboratory of Plant Resources Biorefinery, Guangzhou 510006, P.R. China) Shi Guofeng (School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong Provincial Key Laboratory of Plant Resources Biorefinery, Guangzhou 510006, P.R. China) Zeng Yixi (School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong Provincial Key Laboratory of Plant Resources Biorefinery, Guangzhou 510006, P.R. China) Li Juting (School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong Provincial Key Laboratory of Plant Resources Biorefinery, Guangzhou 510006, P.R. China) Wu Yongyu (School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong Provincial Key Laboratory of Plant Resources Biorefinery, Guangzhou 510006, P.R. China) Zheng Jiahui (School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong Provincial Key Laboratory of Plant Resources Biorefinery, Guangzhou 510006, P.R. China) Xu Anjing (School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong Provincial Key Laboratory of Plant Resources Biorefinery, Guangzhou 510006, P.R. China) Ma Yanqing (School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong Provincial Key Laboratory of Plant Resources Biorefinery, Guangzhou 510006, P.R. China) Zhang Lanyue (School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong Provincial Key Laboratory of Plant Resources Biorefinery, Guangzhou 510006, P.R. China) Li Hui (School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangdong Provincial Key Laboratory of Plant Resources Biorefinery, Guangzhou 510006, P.R. ChinaDepartme)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology Vol.34 No.9
발행연도
2024.9
수록면
1,778 - 1,788 (11page)
DOI
10.4014/jmb.2405.05013

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The disturbance of brain biochemical substances serves as a primary cause and aggravating factor of depression. This study aimed to investigate the principal components of Picea mariana and its effect on reserpine-induced depression mice,w ith its relationship with brain central transmitters and related proteins. The main constituents of P. mariana essential oil (PMEO) were analyzed by GC-MS spectrometry. The quiescent time in the tail suspension test (TST) and forced swim test (FST), along with the weight change of the mice was detected. The number of normal neurons was quantified through Nissl staining. Immunohistochemistry was employed to determine the levels of 5HT-1A and 5HT-2A in the brain. Western blotting was utilized to detect 5HT-2A, CRF and TrkB protein levels. RTqPCR was used to detect the mRNA levels of 5HT-1A, 5HT-2A, TrkB, CRF, and BDNF. The main active ingredients of PMEOs were (-) -bornyl acetate (44.95%), γ-Terpinene (14.17%), and β-Pinene (10.12%). PMEOs effectively improved the retardation and weight loss due to anorexia in depression-like mice. This improvement was associated with an increase in the number of normal neurons. After administering different doses of PMEOs, the levels of 5HT-1A, 5HT-2A, CRF, and TrkB were found to be increased in brain tissue. RT-qPCR revealed that the mRNA levels of CRF, 5HT-1A, and 5HT-2A were generally upregulated, whereas TrkB and BDNF were downregulated. PMEO can effectively alleviate depression induced by reserpine, which may be attributed to its regulation of 5HT-1A, 5HT-2A, CRF and TrkB protein expression, thus reducing brain nerve injury.
#Picea mariana #essential oil #reserpine-induced depression #neurotransmitter #nervous system

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