지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.7
- 수록면
- 817 - 829 (13page)
- DOI
- 10.1007/s13258-024-01516-8
이용수
초록· 키워드
오류제보하기
Background Eukaryotic elongation factor 1A1 (eEF1A1) is an RNA-binding protein that is associated with PARK2 activity in cells, suggesting a possible role in Parkinson’s disease (PD).
Objective To clear whether eEF1A1 plays a role in PD through transcriptional or posttranscriptional regulation.
Methods The GSE68719 dataset was downloaded from the GEO database, and the RNA-seq data of all brain tissue autopsies were obtained from 29 PD patients and 44 neurologically normal control subjects. To inhibit eEF1A1 from being expressed in U251 cells, siRNA was transfected into those cells, and RNA-seq high-throughput sequencing was used to determine the differentially expressed genes (DEGs) and differentially alternative splicing events (ASEs) resulting from eEF1A1 knockdown.
Results eEF1A1 was significantly overexpressed in PD brain tissue in the BA9 area. GO and KEGG enrichment analyses revealed that eEF1A1 knockdown significantly upregulated the expression of the genes CXCL10, NGF, PTX3, IL6, ST6GALNAC3, NUPR1, TNFRSF21, and CXCL2 and upregulated the alternative splicing of the genes ACOT7, DDX10, SHMT2, MYEF2, and NDUFAF5. These genes were enriched in pathways related to PD pathogenesis, such as apoptosis, inflammatory response, and mitochondrial dysfunction.
Conclusion The results suggesting that eEF1A1 involved in the development of PD by regulating the differential expression and alternative splicing of genes, providing a theoretical basis for subsequent research.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Hepatitis B Virus DNA Polymerase Displays an Anti-Apoptotic Effect by Interacting with Elongation Factor-1 Alpha-2 in Hepatoma Cells
Journal of Microbiology and Biotechnology
2021 .01
-
PARK2 gene variants in Korean patients with Parkinson’s disease
Genes & Genomics
2016 .01
-
How are Bayesian and Non-Parametric Methods Doing a Great Job in RNA-Seq Differential Expression Analysis?: A Review
CSAM(Communications for Statistical Applications and Methods)
2015 .03
-
PD-1: A Negative Regulator of Phagocytosis by Tumour-Associated Macrophages in Colon Cancer
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2019 .12
-
Asymmetric induced magnetic moment of top and bottom Pd layers in Pd/Co/Pd trilayer system
한국자기학회 학술연구발표회 논문개요집
2015 .05
-
Pd/Co/Pd 삼층 구조에서 상위 Pd층의 두께에 따른 스핀-궤도 토크의 변화에 관한 연구
한국자기학회 학술연구발표회 논문개요집
2020 .11
-
COEX-Seq: Convert a Variety of Measurements of Gene Expression in RNA-Seq
Genomics & informatics
2018 .01
-
Gene Knockdown of Essential Genes Using Artificial Small RNAs in Escherichia coli
한국미생물학회 학술대회논문집
2017 .04
-
Selected microRNA-192 mutant indicates association with several function genes in bovine cells
Genes & Genomics
2018 .01
-
Spin-Orbit Torque in Pd/Co/Pd(t) Heterostructure
한국자기학회 학술연구발표회 논문개요집
2020 .11
-
Yeast Small Ubiquitin-Like Modifier (SUMO) Protease Ulp2 is Involved in RNA Splicing
발생과 생식
2024 .06
-
The SnRK2 family in pepper (Capsicum annuum L.): genome-wide identifcation and expression analyses during fruit development and under abiotic stress
Genes & Genomics
2020 .01
-
Genome-wide identification, characterisation and expression profile analysis of DEAD-box family genes in sweet potato wild ancestor Ipomoea trifida under abiotic stresses
Genes & Genomics
2020 .01
-
Huge Spin-Transfer Torque in Ferromagnetic Pd/Co/Pd Film
한국자기학회 학술연구발표회 논문개요집
2019 .05
-
Particulate matter-induced gene expression patterns in human-derived cells based on 11 public gene expression datasets
Genes & Genomics
2024 .07
-
Pd(111) 박막의 자성 : 제일원리계산
한국자기학회지
2016 .02
-
Association of serum carotenoid, retinol, and tocopherol concentrations with the progression of Parkinson’s Disease
Nutrition Research and Practice
2017 .04
-
Association of serum carotenoid, retinol, and tocopherol concentrations with the progression of Parkinson’s Disease
Nutrition Research and Practice
2017 .04
-
The Role of Splicing Factors in Adipogenesis and Thermogenesis
Molecules and Cells
2023 .05
-
Profiling of glucose-induced transcription in Sulfolobus acidocaldarius DSM 639
Genes & Genomics
2018 .01
최근 본 자료
댓글(0)
0