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논문 기본 정보

자료유형
학술저널
저자정보
Sangmi Jung (Hongcheon Institute of Medicinal Herb) Jeong-Ran Park (Hongcheon Institute of Medicinal Herb) Moonjin Ra (Hongcheon Institute of Medicinal Herb) Young Han Kim (Hongcheon Institute of Medicinal Herb) Ji Hoon Yu (Daegu-Gyeongbuk Medical Innovation Foundation) Yongjun Lee (Hongcheon Institute of Medicinal Herb)
저널정보
한국생약학회 Natural Product Sciences Natural Product Sciences Vol.26 No.2
발행연도
2020.6
수록면
136 - 143 (8page)
DOI
10.20307/nps.2020.26.2.136

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초록· 키워드

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Psoriasis is one of the most common inflammatory skin disorders, with a global prevalence of 2% – 3%. It is an autoimmune skin disorder characterized by excessive generation of plaques on the skin with typical long-lasting red, itchy, and scaly lesions. In this study, we aimed to elucidate the anti-psoriatic effect of the methanolic extract of Persicaria senticosa (PS), a bioactive edible plant extract used in traditional medicine, using a mouse model of imiquimod (IMQ)-induced psoriasis. The daily topical application of IMQ could induce human psoriasis-like lesion. The extract ameliorated IMQ-induced psoriasis. Furthermore, hematoxylin and eosin staining and the Psoriasis Area and Severity Index (PASI) scores indicated that topical application of PS led to an improvement in erythema, scaling, and thickness scores of the mouse dorsal skin and a considerable decrease in the epidermal thickness of the ear and dorsal skin in the IMQ-induced psoriatic mouse model. We also studied the effect of PS on the proliferation of keratinocytes using HaCaT cells. The extract inhibited cell proliferation and IL-6 and pSTAT3 expression induced by M5 cocktail (comprising interleukin [IL]-1α, IL-17A, IL-22, oncostatin M, and tumor necrosis factor-α) in HaCaT cells. Thus, PS might serve as a potential therapeutic agent for the treatment of psoriasis.

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Abstract
Introduction
Experimental
Results and Discussion
References

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