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논문 기본 정보

자료유형
학술저널
저자정보
Tae-Dong Jeong (Ewha Womans University College of Medicine)
저널정보
대한임상검사정도관리협회 Journal of Laboratory Medicine And Quality Assurance Laboratory Medicine and Quality Assurance 제46권 제2호
발행연도
2024.6
수록면
78 - 86 (9page)
DOI
10.15263/jlmqa.2024.46.2.78

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초록· 키워드

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Since 2011, the Korean Association of External Quality Assessment Service has been conducting accuracy-based creatinine (ABCr) proficiency testing (PT). This study aimed to analyze and report the 2023 ABCr PT program results. The ABCr PT was conducted semi-annually, with three samples used in each round. Six commutable fresh frozen serum samples were used, with a primary reference measurement procedure applied to establish the target creatinine values. In the creatinine test, 1,767 laboratories participated in the first round and 1,776 in the second round. Among the institutions involved in the creatinine test, 666 (37.7%) provided an estimated glomerular filtration rate (eGFR) in the first round and 685 (38.6%) in the second round. The mean percentage bias of the creatinine test varied among samples, with an average of approximately ±1%. The coefficient of variation among laboratories ranged from 4.4% to 8.1%. The acceptance rates of the participating laboratories for creatinine testing ranged from 79.2% to 93.6%. The bias of the kinetic Jaffe method without compensation was relatively large. eGFR is commonly estimated using the Modification of Diet in Renal Disease 4-variable isotope dilution mass spectrometry-traceable equation, followed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2009 and CKD-EPI 2021 equations. The mean bias in the eGFR was 1.9%. The acceptance rate of the eGFR slightly varies depending on the samples and equation used, with values ranging from 97.4% to 99.0%.

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