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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 223 - 229 (7page)
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Purpose: To investigate the overall cancer risk and risk for specific cancers in rheumatoid arthritis (RA) patients in Korea by comparingcancer incidence between RA patients and the general population. Materials and Methods: Individuals diagnosed with RA between 1996 and 2009 who underwent treatment at the Daegu CatholicUniversity Medical Center were retrospectively examined. 1885 patients with RA were included in the analyses. Occurrence ofcancer and death during follow up was ascertained by linking medical records to the Korean Central Cancer Registry and nationaldeath certificates. For comparing cancer incidence between RA patients and general population, standardized incidence ratios(SIR) were calculated. The 95% confidence intervals (CIs) of SIRs were calculated using the shortcut method introduced by Vandenbroucke. Results: The total follow-up time was 10218.9 person-years. During follow up, 100 patients (31 men and 69 women) were diagnosedwith cancer. Both men and women had greater risks of having malignancy, although cancer risk was greater in men. Menshowed increased risks of lung cancer (SIR=5.46, 95% CI: 2.60–9.36) and leukemia (SIR=16.7, 95% CI: 1.58–47.9). Women showedincreased risks of thyroid cancer (SIR=1.75, 95% CI: 1.02–2.68), cervical cancer (SIR=3.65, 95% CI: 1.65–6.42), non-Hodgkin’s lymphoma(SIR=6.47, 95% CI: 2.04–13.4), and gallbladder cancer (SIR=3.87, 95% CI: 1.01–8.60). Disease-modifying anti-rheumaticdrugs usage and cancer were not related: the relative risks of developing malignancy were not elevated for each medicine. Conclusion: The overall cancer incidence was increased in Korean men and women with RA. Increased risk of specific malignancydiffered according to sex.
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참고문헌 (27)
참고문헌 신청
Parikh-Patel A / 2009 / Risk of cancer among rheumatoid arthritis patients in California / Cancer Causes Control 20:1001~1010
Yamada T / 2011 / Incidence of malignancy in Japanese patients with rheumatoid arthritis / Rheumatol Int 31:1487~1492
Chen YJ / 2011 / The risk of cancer in patients with rheumatoid arthritis : a nationwide cohort study in Taiwan / Arthritis Rheum 63:352~358
Simon TA / 2015 / Incidence of malignancy in adult patients with rheumatoid arthritis : a meta-analysis / Arthritis Res Ther 17:212
Hashimoto A / 2015 / Incidence of malignancy and the risk of lymphoma in Japanese patients with rheumatoid arthritis compared to the general population / J Rheumatol 42:564~571
Yamada T / 2011 / Incidence of malignancy in Japanese patients with rheumatoid arthritis / Rheumatol Int 31:1487~1492
Chen YJ / 2011 / The risk of cancer in patients with rheumatoid arthritis : a nationwide cohort study in Taiwan / Arthritis Rheum 63:352~358
Simon TA / 2015 / Incidence of malignancy in adult patients with rheumatoid arthritis : a meta-analysis / Arthritis Res Ther 17:212
Hashimoto A / 2015 / Incidence of malignancy and the risk of lymphoma in Japanese patients with rheumatoid arthritis compared to the general population / J Rheumatol 42:564~571
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