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논문 기본 정보

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저자정보
An Jin (Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.) Lee Chea Eun (Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Kim Seo-Young (Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) 박소영 (Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.Division of Pulmonary, Allergy and Critical Care Medicine, Chung-Ang University Gwangmyeong Medical Ce) Kim Sujeong (Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.) Sim Da Woon (Department of Allergy and Clinical Immunology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.) Yang Min-Suk (Department of Internal Medicine, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, Korea.) 박한기 (Department of Allergy and Clinical Immunology, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.) Kim Sae-Hoon (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.) Kim Sang-Heon (Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.) 예영민 (Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.Clinical Trial Center, Ajou University Medical Center, Suwon, Korea.) Lee Jae-Hyun (Department of Internal Medicine, Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.) 허규영 (Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.) Park Hye-Kyung (Department of Internal Medicine, Pusan National University College of Medicine, Busan, Korea.) Koh Young-Il (Department of Allergy and Clinical Immunology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.) Park Jung Won (Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.) Lee Jaechun (Department of Internal Medicine, Jeju National University Hospital, Jeju, Korea.Department of Internal Medicine, Jeju National University, College of Medicine, Jeju, Korea.) Lee Byung-Jae (Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.) Kim Tae-Bum (Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research AAIR Vol.16 No.3
발행연도
2024.5
수록면
308 - 316 (9page)
DOI
10.4168/aair.2024.16.3.308

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초록· 키워드

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The diagnosis of anaphylaxis is based on the clinical history. The utility of tryptase measurements in clinical setting is limited. Mas-related G protein-coupled receptor-X2 (MRGPRX2) is expressed in mast cells and is involved in the degranulation of these cells. We evaluated the potential of MRGPRX2 as a diagnostic biomarker in patients with iodinated contrast media (ICM)-induced immediate hypersensitivity reactions (IHRs). A total of 173 patients with documented ICM-induced IHR within 4 months from registration were enrolled and skin tests for the culprit ICM were performed. The time interval was evaluated as the duration between the onset of ICM-induced IHR and the measurement of serum MRGPRX2 levels. Serum MRGPRX2 concentration was determined using an enzyme-linked immunosorbent assay kit. Of the 173 patients, 33 and 140 were included in the anaphylaxis and non-anaphylaxis groups, respectively. Serum MRGPRX2 levels were significantly higher in the anaphylaxis than in the non-anaphylaxis group (29.9 ± 24.1 vs. 20.7±17.5, P = 0.044). Serum MRGPRX2 showed a moderate predictive ability for anaphylaxis, with an area under the curve of 0.61 (P = 0.058). When groups were classified based on the time interval, T1(0-2months) and T2 (2-4months), patients with anaphylaxis had higher MRGPRX2 levels compared to the non-anaphylaxis group in the T2 group (36.5±19.2 vs. 20.5±19.0, P = 0.035). This pilot study shows that serum MRGPRX2 is a potential long-term biomarker for predicting anaphylaxis, particularly ICM-induced anaphylaxis. Further studies are needed to determine the role of MRGPRX2 in anaphylaxis in a larger population of patients with various drug-induced IHRs.
#Hypersensitivity #drug #anaphylaxis #tryptase

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