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논문 기본 정보

자료유형
학술저널
저자정보
Nannan Jiang (Chinese Academy of Medical Sciences) Jia Yin (Chinese Academy of Medical Sciences)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.8 No.4
발행연도
2016.1
수록면
353 - 361 (9page)

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Purpose: Comprehensive evaluation of anaphylaxis in China is currently lacking. In this study, we characterized the clinical profiles, anaphylactic triggers, and emergency treatment in pediatric and adult patients. Methods: Outpatients diagnosed with “anaphylaxis” or “severe allergic reactions” in the Department of Allergy, Peking Union Medical College Hospital from January 1, 2000 to June 30, 2014 were analyzed retrospectively. Results: A total of 1,952 episodes of anaphylaxis in 907 patients were analyzed (78% were adults and 22% were children). Foods are the most common cause (77%), followed by idiopathic etiologies (15%), medications (7%) and insects (0.6%). In food-induced anaphylaxis, 62% (13/21) of anaphylaxis in infants and young children (0-3 years of age) were triggered by milk, 59% (36/61) of anaphylaxis in children (4-9 years of age) were triggered by fruits/vegetables, while wheat was the cause of anaphylaxis in 20% (56/282) of teenagers (10-17 years of age) and 42% (429/1,016) in adults (18-50 years of age). Mugwort pollen sensitization was common in patients with anaphylaxis induced by spices, fruits/vegetables, legume/peanuts, and tree nuts/seeds, with the prevalence rates of 75%, 67%, 61%, and 51%, respectively. Thirty-six percent of drug-induced anaphylaxis was attributed to traditional Chinese Medicine. For patients receiving emergency care, only 25% of patients received epinephrine. Conclusions: The present study showed that anaphylaxis appeared to occur more often in adults than in infants and children, which were in contrast to those found in other countries. In particular, wheat allergens played a prominent role in triggering food-induced anaphylaxis, followed by fruits/vegetables. Traditional Chinese medicine was a cause of drug-induced anaphylaxis. Furthermore, exercise was the most common factor aggravating anaphylaxis. Education regarding the more aggressive use of epinephrine in the emergency setting is clearly needed.

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참고문헌 (34)

참고문헌 신청
Simons FE / 2010 / Anaphylaxis / J Allergy Clin Immunol 125(Suppl 2):S161~S181 google schola Sheikh A / 2008 / Trends in national incidence, lifetime prevalence and adrenaline prescribing for anaphylaxis in England / J R Soc Med 101:139~143 google schola Huang F / 2012 / Anaphylaxis in a New York City pediatric emergency department: triggers, treatments, and outcomes / J Allergy Clin Immunol 129:162~168.e1 google schola Ben-Shoshan M / 2013 / Anaphylaxis treated in a Canadian pediatric hospital:Incidence, clinical characteristics, triggers, and management / J Allergy Clin Immunol 132:739~741.e3 google schola Banerji A / 2010 / Repeat epinephrine treatments for food-related allergic reactions that present to the emergency department / Allergy Asthma Proc 31:308~316 google schola

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