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논문 기본 정보

자료유형
학술저널
저자정보
Okan Oktar (Department of Gynecologic Oncology, Ankara Etlik City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Vakkas Korkmaz (1 Department of Gynecologic Oncology, Ankara Etlik City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Alp Tokalıoğlu (Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Çağatayhan Öztürk (Ankara University, Faculty of Medicine, Ankara, Turkey) Özgür Erdoğan (Department of Gynecologic Oncology, Tepecik Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Izmir, Turkey) Yeşim Uçar (Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Hande Esra Koca Yıldırım (Department of Gynecologic Oncology, Ankara Etlik City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Candost Hanedan (Department of Gynecologic Oncology, Ankara Etlik City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Fatih Kılıç (Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Burak Ersak (Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Necim Yalçın (Department of Gynecologic Oncology, Antalya Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Antalya, Turkey) Fatma Özmen (Department of Gynecologic Oncology, Adana City Hospital, Faculty of Medicine, University of Health Sciences, Adana, Turkey) Alper Kahraman (Department of Gynecologic Oncology, Antalya Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Antalya, Turkey) Selin Aktürk Esen (Department of Medical Oncology, Ankara Bilkent City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Sevda Baş (Department of Gynecologic Oncology, Adana City Hospital, Faculty of Medicine, University of Health Sciences, Adana, Turkey) Emel Doğan Özdaş (Department of Gynecologic Oncology, Tepecik Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Izmir, Turkey) İlker Selçuk (Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Gökhan Uçar (Department of Medical Oncology, Ankara Bilkent City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Özgür Koçak (Department of Gynecologic Oncology, Hitit University, Corum, Turkey) Caner Çakır (Department of Gynecologic Oncology, Ankara Etlik City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Sevgi Koç (Department of Gynecologic Oncology, Etlik Zubeyde Hanim Women’s Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Çiğdem Kılıç (Department of Gynecologic Oncology, Hitit University, Corum, Turkey) Günsu Kimyon Cömert (Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Işın Üreyen (Department of Gynecologic Oncology, Antalya Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Antalya, Turkey) Tayfun Toptaş (Department of Gynecologic Oncology, Antalya Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Antalya, Turkey) Mehmet Ali Narin (Department of Gynecologic Oncology, Adana City Hospital, Faculty of Medicine, University of Health Sciences, Adana, Turkey) Tolga Taşçı (Department of Gynecologic Oncology, Bahcesehir University, Istanbul, Turkey) Salih Taşkın (Ankara University, Faculty of Medicine, Ankara, Turkey) Nurettin Boran (Department of Gynecologic Oncology, Etlik Zubeyde Hanim Women’s Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Muzaffer Sancı (Department of Gynecologic Oncology, Tepecik Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Izmir, Turkey) Fahriye Tuğba Köş (Department of Medical Oncology, Ankara Bilkent City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Özlem Moraloğlu Tekin (Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Yaprak Engin Üstün (Department of Gynecologic Oncology, Etlik Zubeyde Hanim Women’s Health Training and Research Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey) Fırat Ortaç (Ankara University, Faculty of Medicine, Ankara, Turkey) Taner Turan (Department of Gynecologic Oncology, Ankara Bilkent City Hospital, Faculty of Medicine, University of Health Sciences, Ankara, Turkey)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.35 No.3
발행연도
2024.5
수록면
1 - 14 (14page)
DOI
https://doi.org/10.3802/jgo.2024.35.e39

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Objective: To define the clinical, histopathological features and the prognostic factorsaffecting sur vival in patients with adult granulosa cell tumors of the ovar y (AGCT). Methods: A 322 patients whose final pathologic outcome was AGCT treated at nine tertiar yoncology centers between 1988 and 2021 participated in the study. Results: The mean age of the patients was 51.3±11.8 years and ranged from 21 to 82 years. According to the International Federation of Gynecology and Obstetrics 2014, 250 (77.6%)patients were stage I, 24 (7.5%) patients were stage II, 20 (6.2%) patients were stage III,and 3 (7.8%) were stage IV. Lymphadenectomy was added to the surgical procedure in 210(65.2%) patients. Lymph node involvement was noted in seven (3.3%) patients. Peritonealcytology was positive in 19 (5.9%) patients, and 13 (4%) had metastases in the omentum. Of285 patients who under went hysterectomy, 19 (6.7%) had complex hyperplasia with atypia/endometrial intraepithelial neoplasia, and 8 (2.8%) had grade 1 endometrioid endometrialcarcinoma. It was found that 93 (28.9%) patients in the study group received adjuvanttreatment. Bleomycin, etoposide, cisplatin was the most commonly used chemotherapyprotocol. The median follow-up time of the study group was 41 months (range, 1–276months). It was noted that 34 (10.6%) patients relapsed during this period, and 9 (2.8%) patients died because of the disease. The entire cohort had a 5-year disease-free sur vival(DFS) of 86% and a 5-year disease-specific sur vival of 98%. Recurrences were obser ved onlyin the pelvis in 13 patients and the extra-abdominal region in 7 patients. The recurrence rateincreased 6.168-fold in patients with positive peritoneal cytology (95% confidence inter val[CI]=1.914–19.878; p=0.002), 3.755-fold in stage II–IV (95% CI=1.275–11.063; p=0.016), and2.517-fold in postmenopausal women (95% CI=1.017–6.233; p=0.046) increased. Conclusion: In this study, lymph node involvement was detected in 3.3% of patients withAGCT. Therefore, it was concluded that lymphadenectomy can be avoided in primar y surgicaltreatment. Positive peritoneal cytology, stage, and menopausal status were independentprognostic predictors of DFS.
#Keywords: Granulosa Cell #Disease-Free Sur vival #Prognostic Factors #Ovarian Carcinoma #Keywords #Granulosa Cell, Disease-Free Sur vival, Prognostic Factors, Ovarian Carcinoma

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