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논문 기본 정보

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저자정보
Yoon Jiyoung (Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea) Hong Seung Wook (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Han Kyung-Do (Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea) Lee Seung-Woo (Department of Medical Statistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.) Shin Cheol Min (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of) Park Young Soo (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea) Kim Nayoung (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of) Lee Dong Ho (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of) Kim Joo Sung (Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea) Yoon Hyuk (Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver Vol.18 No.3
발행연도
2024.5
수록면
489 - 497 (9page)
DOI
10.5009/gnl230152

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초록· 키워드

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Background/Aims: Pneumocystis jirovecii pneumonia (PJP) is a rare but potentially fatal infection. This study was conducted to investigate the risk factors for PJP in inflammatory bowel disease (IBD) patients. Methods: This nationwide, population-based study was conducted in Korea using claims data. Cases of PJP were identified in patients diagnosed with ulcerative colitis (UC) or Crohn’s disease (CD) between 2010 and 2017, and the clinical data of each patient was analyzed. Dual and triple therapy was defined as the simultaneous prescription of two or three of the following drugs: steroids, calcineurin inhibitors, immunomodulators, and biologics. Results: During the mean follow-up period (4.6±2.3 years), 84 cases of PJP were identified in 39,462 IBD patients (31 CD and 53 UC). For CD patients, only age at diagnosis >40 years (hazard ratio [HR], 6.12; 95% confidence interval [CI], 1.58 to 23.80) was significantly associated with the risk of PJP, whereas in UC patients, diagnoses of diabetes (HR, 2.51; 95% CI, 1.19 to 5.31) and chronic obstructive pulmonary disease (HR, 3.41; 95% CI, 1.78 to 6.52) showed significant associations with PJP risk. Triple therapy increased PJP risk in both UC (HR, 3.90; 95% CI, 1.54 to 9.88) and CD patients (HR, 5.69; 95% CI, 2.32 to 14.48). However, dual therapy increased PJP risk only in UC patients (HR, 2.53; 95% CI, 1.36 to 4.70). Additionally, 23 patients (27%) received intensive care treatment, and 10 (12%) died within 30 days. Conclusions: PJP risk factors differ in CD and UC patients. Considering the potential fatality of PJP, prophylaxis should be considered for at-risk IBD patients.
#Ulcerative colitis #Cohort studies #Crohn disease #Inflammatory bowel diseases #Pneumocystis jirovecii pneumonia

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