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논문 기본 정보

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학술저널
저자정보
Mazen Elsheikh (Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt) Lekan Akanbi (Department of Gastroenterology and Hepatology, University of Missouri Health Care, Columbia, MO, USA) Lisbeth Selby (Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, KY, USA) Bahaaeldeen Ismail (Division of Digestive Diseases and Nutrition, University of Kentucky, Lexington, KY, USA)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.30 No.2
발행연도
2024.4
수록면
156 - 165 (10page)
DOI
10.5056/jnm23017

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Background/AimsThere is an increased incidence of gastroesophageal reflux disease (GERD) after lung transplantation (LT) that can be associated with graft dysfunction. It is unclear if the underlying esophageal motility changes in GERD are different following LT. This study aimed to use esophageal high-resolution manometry (HRM) to explore GERD mechanisms in LT recipients compared to matched controls. MethodsThis was a retrospective study including patients with pathologic acid reflux who underwent HRM and pH testing at our healthcare facility July 2012 to October 2019. The study included 12 LT recipients and 36 controls. Controls were matched in a 1:3 ratio for age, gender, and acid exposure time (AET). ResultsLT recipients had less hypotensive esophagogastric junction (EGJ) (mean EGJ-contractile integral 89.2 mmHg/cm in LT vs 33.9 mmHg/cm in controls, P < 0.001). AET correlated with distal contractile integral and total EGJ-contractile integral only in LT group (r = –0.79, P = 0.002 and r = –0.57, P = 0.051, respectively). ConclusionsFollowing LT, acid reflux is characterized by a less hypotensive EGJ compared to controls with similar AET. The strongest correlation with AET after LT was found to be esophageal peristaltic vigor. These results add to the understanding of reflux after LT and may help tailor an individualized treatment plan.

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