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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제27권 제4호
- 발행연도
- 2017.1
- 수록면
- 856 - 867 (12page)
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Supplement of dietary fibers (DF) is regarded as one of the most effective way to prevent and relieve chronic diseases caused by long-term intake of a high-fat diet in the current society. The health benefits of soluble dietary fibers (SDF) have been widely researched and applied, whereas the insoluble dietary fibers (IDF), which represent a higher proportion in plant food, were mistakenly thought to have effects only in fecal bulking. In this article, we proved the anti-obesity and glucose homeostasis improvement effects of IDF from pear pomace at first, and then the mechanisms responsible for these effects were analyzed. The preliminary study by real-time PCR and ELISA showed that this kind of IDF caused more changes in the gut microbiota compared with in satiety hormone or in hepatic metabolism. Further analysis of the gut microbiota by high-throughput amplicon sequencing showed IDF from pear pomace obviously improved the structure of the gut microbiota. Specifically, it promoted the growth of Bacteroidetes and inhibited the growth of Firmicutes. These results are coincident with previous hypothesis that the ratio of Bacteroidetes/Firmicutes is negatively related with obesity. In conclusion, our results demonstrated IDF from pear pomace could prevent high-fat diet-induced obesity in rats mainly by improving the structure of the gut microbiota.
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참고문헌 (23)
참고문헌 신청
[학술지(정기간행물
Aljuraiban GS / 2015 / Total, insoluble and soluble dietary fib re i ntake in r elation to blood p ressure: t he I NTERMAP Study / Br. J. Nutr 114 : 1534 ~
Cai DS / 2005 / Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappa B / Nat. Med 11 : 183 ~ 190
Chang CJ / 2015 / Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota / Nat. Commun 6 : 7489 ~
Delzenne NM / 2002 / Prebiotics and lipid metabolism / Curr. Opin. Lipidol 13 : 61 ~ 67
Aljuraiban GS / 2015 / Total, insoluble and soluble dietary fib re i ntake in r elation to blood p ressure: t he I NTERMAP Study / Br. J. Nutr 114 : 1534 ~
Cai DS / 2005 / Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappa B / Nat. Med 11 : 183 ~ 190
Chang CJ / 2015 / Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota / Nat. Commun 6 : 7489 ~
Delzenne NM / 2002 / Prebiotics and lipid metabolism / Curr. Opin. Lipidol 13 : 61 ~ 67
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