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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.5
- 수록면
- 1,230 - 1,230 (1page)
- DOI
- 10.1038/s12276-024-01229-8
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초록· 키워드
오류제보하기
We read and had great interest in the article written by Xuan et al.1. This study revealed that mice exhibited lung and intestinal mucosal damage, gut microbiota dysbiosis, and elevated lactate and N-cadherin levels after 28 days of exposure to nano-microplastics. In addition, lactate accumulation was strongly associated with an imbalance in lactic acid bacteria in the gut. Furthermore, no lactate accumulation was observed in germ-free mice, while depletion of the gut microbiota using a cocktail of antibiotics produced similar results. Mechanistically, elevated lactate level trigger activation of the HIF1a/PTBP1 pathway, which exacerbates nano-microplastic-induced lung damage through modulation of the epithelial–mesenchymal transition (EMT). However, we would like to discuss this topic further.
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