메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Song Jae Geun (College of Pharmacy, Dongguk University-Seoul) Lee Sang Hoon (College of Pharmacy, Dongguk University-Seoul) 한효경 (동국대학교)
저널정보
한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation Vol.54 No.3
발행연도
2024.5
수록면
403 - 414 (12page)
DOI
10.1007/s40005-024-00663-0

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Purpose Most protein drugs on the market are available in injectable dosage forms due to their metabolic instability and low membrane permeability, demanding more patient-friendly delivery systems for biomacromolecules. Therefore, this study aimed to develop organic clay-based dissolving microneedles for the effective transdermal delivery of protein drugs. Methods The core nanocomplex (AC-Lira) was prepared via electrostatic interaction of aminoclay (AC) with liraglutide (Lira), a glucagon-like peptide-1 receptor agonist. AC-Lira was then mixed with polyvinyl alcohol (PVA) solution and poured into a reverse polydimethylsiloxane mold to fabricate the drug-loaded dissolving microneedles (AC-Lira-PVA-MNs). The in vitro and in vivo effectiveness of AC-Lira-PVA-MNs as the transdermal delivery system of protein drugs were evaluated using various analytical methods. Results AC-Lira-PVA-MNs displayed a uniform pyramidal shape with a tip length of approximately 600 μm and good mechanical strength (0.83 ± 0.040 N/needle). Furthermore, the conformational stability of Lira was maintained in AC-Lira- PVA-MNs. At pH 7.0, AC-Lira-PVA-MNs exhibited rapid dissolution, leading to almost complete (> 90%) drug release within 1 h. In-vitro skin insertion studies using pig cadaver skin also confirmed that AC-Lira-PVA-MNs achieved rapid and complete dissolution of needles within 1 h after skin insertion. In rats, the systemic drug exposure after AC-Lira-PVAMNs administration was comparable to that after subcutaneous (SC) injection. In addition, AC-Lira-PVA-MNs effectively reduced blood glucose level, food intake, and body weight in type 2 diabetic rats to a similar extent to SC injection of Lira. Conclusion The results suggest that organic clay-based dissolving microneedles can be a promising transdermal delivery system for protein drugs.

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

최근 본 자료

전체보기

댓글(0)

0