지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제51권 제5호
- 발행연도
- 2021.9
- 수록면
- 571 - 577 (7page)
- DOI
- 10.1007/s40005-021-00519-x
이용수
초록· 키워드
오류제보하기
Purpose The stratum corneum is an important skin barrier that prevents the loss of water from the skin and protects the body from exogenous substances, such as chemicals and microbes. A microneedle array, which contains abundant micron-sized needles, can enhance the skin permeation of pharmaceutical or cosmetic active compounds by creating micropores through the epidermis and dermis. However, these micropores also cause the loss of water from the skin. Thus, our concept was to develop a dissolving microneedle (DMN) array that consisted of water-holding materials to compensate for the water loss induced by micropore formation.
Methods DMN arrays were prepared from collagen or sodium hyaluronate (HYA) and polyvinyl alcohol (PVA) and then evaluated for their insertion potential, dissolution, ex vivo skin hydration and transepidermal water loss (TEWL).
Results DMN arrays with HYA and PVA, at various ratios, provided sufficient mechanical strength to penetrate through the skin and dissolved in the skin within 10 min. These arrays also increased skin hydration for a few hours after they had been removed, and the TEWL was less than that from other microneedle arrays.
Conclusion Our DMN arrays with HYA and PVA had a moisturizing effect on the skin.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bediz B / 2014 / Dissolvable microneedle arrays for intradermal delivery of biologics: fabrication and application / Pharm Res 31(1):117~135
Cheng Z / 2020 / Preparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of curcumin / Drug DelivTransl Res 10:1520~1530
Dabboue H / 2015 / Assessing the impact of mechanical damage on fullthickness porcine and human skin using an in vitro approach / Biomed Res Int 434623:1~10
de Faria JC / 1995 / Skin aging and collagen / Rev HospClinFac Med Sao Paulo 50(Suppl):39~43
Gomaa YA / 2010 / Effects of microneedle length, density, insertion time and multiple applications on human skin barrier function: assessments by transepidermal water loss / Toxicol In Vitro 24(7):1971~1978
Cheng Z / 2020 / Preparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of curcumin / Drug DelivTransl Res 10:1520~1530
Dabboue H / 2015 / Assessing the impact of mechanical damage on fullthickness porcine and human skin using an in vitro approach / Biomed Res Int 434623:1~10
de Faria JC / 1995 / Skin aging and collagen / Rev HospClinFac Med Sao Paulo 50(Suppl):39~43
Gomaa YA / 2010 / Effects of microneedle length, density, insertion time and multiple applications on human skin barrier function: assessments by transepidermal water loss / Toxicol In Vitro 24(7):1971~1978
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