지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.9
- 수록면
- 182 - 189 (8page)
- DOI
- 10.20307/nps.2024.30.3.182
이용수
초록· 키워드
오류제보하기
Ginger (Zingiber officinale Roscoe) is widely utilized in Thailand’s healthcare system to alleviate motion sickness-induced nausea and vomiting. Its anti-emetic properties are attributed to various phenolic constituents, primarily gingerols and shogaols, which can vary due to processing and environmental factors. Tracking these compounds is quite complex. Therefore, this study aims to scientifically verify a practical quantitative approach for assessing active constituents, in terms of phenolic profiles, using ginger orodispersible tablets (ODTs) from standardized extracts as the target. The standardized ginger extract, quantified in 6-gingerol via validated HPLC, was combined with the superdisintegrant, sodium starch glycolate, using the wet granulation technique to prepare the ODTs. The optimized formulation met Pharmacopoeia standards, exhibiting desirable characteristics that can be used as a sample prototype for assessing the total phenolic content (TPC) using the modified Folin-Ciocalteu (F-C) assay. Determining the phenolic profiles in both the standardized ginger extracts and the tablets proved effective, facilitating the accurate quantification of total active constituents. This was particularly useful for handling multiple samples during dissolution tests. This study contributes to frontier knowledge on the phenolic profiles in standardized ginger extracts and theirs ODTs, which play an important role in interpreting the amounts of active constituents in the ODTs for their antiemetic properties.
목차
Abstract
Introduction
Experimental
Results and Discussion
References
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