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논문 기본 정보

자료유형
학술저널
저자정보
Ayoung Lee (Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea) Choe Jung Wan (Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea) Jung Sung Woo (Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea) Jae Youn Park (Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea) Ik Yoon (Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea) Seung Young Kim (Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea)
저널정보
대한상부위장관 헬리코박터학회 Korean Journal of Helicobacter Upper Gastrointestinal Research Korean Journal of Helicobacter Upper Gastrointestinal Research 제24권 제1호
발행연도
2024.3
수록면
52 - 57 (6page)
DOI
10.7704/kjhugr.2023.0045

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초록· 키워드

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Objectives: Epidemiological studies have shown an inverse association between Helicobacter pylori infection and ulcerative colitis (UC). In this study, we investigated the protective effects of H. pylori infection on the severity of UC. Methods: This single-center study included 316 patients with newly diagnosed UC based on findings of colonoscopy and upper endoscopy for H. pylori evaluation between January 1994 and December 2015. Patients’ medical records were retrospectively reviewed, and severity of UC was assessed based on endoscopic findings, clinical symptoms, treatment regimens, and Mayo scores. Results: The prevalence of H. pylori infection in patients with UC was 74/316 (23.4%). Based on upper endoscopic findings, the percentage of patients with duodenal ulcers was significantly higher in the H. pylori positive group than that in the H. pylori negative group (27.0% vs. 11.6%, p=0.022). Disease extent and endoscopic severity showed no significant intergroup difference (p=0.765 and p=0.803, respectively). Endoscopic severity was unaffected by the H. pylori infection status, based on the extent of endoscopically documented disease and endoscopic findings. Furthermore, UC-related symptom severity assessed on the basis of stool frequency, rectal bleeding severity, and rate of admission necessitated by UC aggravation was not associated with H. pylori infection (p=0.185, 0.144, and 0.182, respectively). Use of steroids as induction therapy for severe UC did not differ with regard to H. pylori infection (p=0.327). No intergroup difference was observed in disease severity of UC classified using the Mayo score (p=0.323). Conclusions: H. pylori infection was detected in approximately 25.0% of patients with UC. However, the H. pylori infection status was not associated with the severity of UC based on endoscopic disease activity, patients’ symptoms, steroid use, or the Mayo clinic score.

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