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논문 기본 정보

자료유형
학술저널
저자정보
Aida Alizamir (Hamadan University of Medical Sciences) Mohammad Amin Amini (Hamadan University of Medical Sciences) Ashkan Karbasi (Hamadan University of Medical Sciences) Mehdi Beyrami (Hamadan University of Medical Sciences)
저널정보
전남대학교 의과학연구소 전남의대학술지 Chonnam Medical Journal Vol.60 No.1
발행연도
2024.1
수록면
21 - 26 (6page)

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초록· 키워드

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There is no doubt that the incidence of cancer sufferers is rising in the world, and it is estimated that in the next several decades, the number of people suffering from malignancies or the cancer rate will double. Diagnostic and therapeutic targeting of noncoding RNAs (ncRNAs), especially microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), represent an excellent approach for cancer diagnosis and treatment, as well as many other diseases. One of the latest miRNAs is miR-4492, upregulating some genes in tumor tissues including ROMO1, HLA-G, NKIRAS2, FOXK1, and UBE2C. It represents an attractant example of a miRNA acting at multiple levels to affect the same malignancy hallmark. Based on the studies, miR-4492 plays a key role in several cancers such as, breast cancer, bladder cancer, osteosarcoma, glioblastoma multiforme, hepatocellular carcinoma, colorectal cancer, and ovarian cancer. Putting it all together, identifying the precise mechanisms of miR-4492 in the pathogenesis of cancer, could pave the way to find better diagnostic and therapeutic strategies for cancer sufferers. For this reason, it might be a novel potential diagnostic biomarker and therapeutic target for neoplasms.

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