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논문 기본 정보

자료유형
학술저널
저자정보
Richard J. Auchus (Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, USA) Suranut Charoensri (Division of Endocrinology and Metabolism, Department of Medicine, Khon Kaen University, Thailand)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.39 No.1
발행연도
2024.2
수록면
73 - 82 (10page)
DOI
https://doi.org/10.3803/EnM.2024.1894

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초록· 키워드

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Adrenal insufficiency (AI) can be classified into three distinct categories based on its underlying causes: primary adrenal disorders, secondary deficiencies in adrenocorticotropin, or hypothalamic suppression from external factors, most commonly glucocorticoid medications used for anti-inflammatory therapy. The hallmark clinical features of AI include fatigue, appetite loss, unintentional weight loss, low blood pressure, and hyponatremia. Individuals with primary AI additionally manifest skin hyperpigmentation, hyperkalemia, and salt craving. The diagnosis of AI is frequently delayed due to the non-specific symptoms and signs early in the disease course, which poses a significant challenge to its early detection prior to an adrenal crisis. Despite the widespread availability of lifesaving glucocorticoid medications for decades, notable challenges persist, particularly in the domains of timely diagnosis while simultaneously avoiding misdiagnosis, patient education for averting adrenal crises, and the determination of optimal replacement therapies. This article reviews recent advancements in the contemporary diagnostic strategy and approaches to optimal treatment for AI.

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