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논문 기본 정보

자료유형
학술저널
저자정보
Park Mincheol (Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.Department of Neurology, Chung-Ang University College of Medicine and Graduate School of Medicine, Gwangmyeong Ho) Baik Kyoungwon (Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.) Sohn Young H. (Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.) Ye Byoung Seok (Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.)
저널정보
대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제23권 제1호
발행연도
2024.1
수록면
11 - 21 (11page)
DOI
10.12779/dnd.2024.23.1.11

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초록· 키워드

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Background and Purpose: Although dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia, its clinical prevalence is low. We developed a short and easy-to-complete DLB screening questionnaire (DLBSQ) to raise diagnostic sensitivity in routine clinical settings. Methods: A total of 501 participants were retrospectively enrolled, including 71 controls, 184 patients without DLB, and 246 patients with probable DLB. All patients underwent clinical evaluation, including core features of DLB, the DLBSQ, brain magnetic resonance imaging, and detailed neuropsychological assessments. The diagnostic performance of the DLBSQ for probable DLB was investigated using a receiver operating characteristic curve analysis. Results: Total DLBSQ score was associated with visuospatial and frontal/executive dysfunction and the diagnosis of probable DLB. The area under the receiver operating characteristic curve for total DLBSQ score was 0.727. Youden’s method revealed an optimal cutoff value of 3. The sensitivity and specificity of the DLBSQ were 68.7% and 62.4%, respectively. Its discriminating performance improved when cognitive test profiles were additionally considered (area under the curve: 0.822, sensitivity: 80.6%, and specificity: 70.4%). Conclusions: The DLBSQ might be a useful screening tool for DLB in routine clinical practice with good sensitivity and specificity.

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