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논문 기본 정보

자료유형
학술저널
저자정보
Na Seunghee (Department of Neurology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.) Kang Dong Woo (Department of Psychiatry, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.) Kim Geon Ha (Department of Neurology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Korea.) Kim Ko Woon (Department of Neurology, Jeonbuk National University Hospital, Jeonbuk National University College of Medicine, Jeonju, Korea.) Kim Yeshin (Department of Neurology, Kangwon National University Hospital, Kangwon National University College of Medicine, Chuncheon, Korea.) Kim Hee-Jin (Department of Neurology, Hanyang University Hospital, College of Medicine, Hanyang University, Seoul, Korea.) Park Kee Hyung (Department of Neurology, College of Medicine, Gachon University Gil Medical Center, Incheon, Korea.) Park Young Ho (Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.) Byeon Gihwan (Department of Psychiatry, Kangwon National University Hospital, Kangwon National University College of Medicine, Chuncheon, Korea.) Suh Jeewon (Department of Neurology, National Medical Center, Seoul, Korea.) Shin Joon Hyun (Dr Shin’s Neurology Clinic, Wonju, Korea.) Shim YongSoo (Department of Neurology, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.) Yang YoungSoon (Department of Neurology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University School of Medicine, Cheonan, Korea.) Um Yoo Hyun (Department of Psychiatry, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.) Oh Seong-il (Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea.) Wang Sheng-Min (Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.) Yoon Bora (Department of Neurology, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea.) Yoon Hai-Jeon (Department of Nuclear Medicine, Ewha Womans University College of Medicine, Seoul, Korea.) Lee Sun Min (Department of Neurology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.) Lee Juyoun (Department of Neurology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.) Lee Jin San (Department of Neurology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea.) Rhee Hak Young (Department of Neurology, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul, Korea.) Lim Jae-Sung (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Jung Young Hee (Department of Neurology, Myungji Hospital, Goyang, Korea.) Chin Juhee (Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.) Hong Yun Jeong (Department of Neurology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea.) Jang Hyemin (Department of Neurology, Seoul National University Hospital, Seoul, Korea.) Choi Hongyoon (Department of Nuclear Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.) Choi Miyoung (Division of Healthcare Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea.) Jang Jae-Won (Department of Neurology, Kangwon National University Hospital, Kangwon National University College of Medicine, Chuncheon, Korea.)
저널정보
대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제23권 제1호
발행연도
2024.1
수록면
54 - 66 (13page)
DOI
10.12779/dnd.2024.23.1.54

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초록· 키워드

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Background and Purpose: Dementia subtypes, including Alzheimer’s dementia (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD), pose diagnostic challenges. This review examines the effectiveness of 18F-Fluorodeoxyglucose Positron Emission Tomography (18F-FDG PET) in differentiating these subtypes for precise treatment and management. Methods: A systematic review following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines was conducted using databases like PubMed and Embase to identify studies on the diagnostic utility of 18F-FDG PET in dementia. The search included studies up to November 16, 2022, focusing on peer-reviewed journals and applying the gold-standard clinical diagnosis for dementia subtypes. Results: From 12,815 articles, 14 were selected for final analysis. For AD versus FTD, the sensitivity was 0.96 (95% confidence interval [CI], 0.88–0.98) and specificity was 0.84 (95% CI, 0.70–0.92). In the case of AD versus DLB, 18F-FDG PET showed a sensitivity of 0.93 (95% CI 0.88-0.98) and specificity of 0.92 (95% CI, 0.70–0.92). Lastly, when differentiating AD from non-AD dementias, the sensitivity was 0.86 (95% CI, 0.80–0.91) and the specificity was 0.88 (95% CI, 0.80–0.91). The studies mostly used case-control designs with visual and quantitative assessments. Conclusions: 18F-FDG PET exhibits high sensitivity and specificity in differentiating dementia subtypes, particularly AD, FTD, and DLB. This method, while not a standalone diagnostic tool, significantly enhances diagnostic accuracy in uncertain cases, complementing clinical assessments and structural imaging.
#Keywords: Fluorodeoxyglucose F18 #Positron Emission Tomography Computed Tomography #Dementia #Meta-Analysis #Alzheimer's Disease #Frontotemporal Dementia #Lewy Body Disease #Keywords #Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Dementia, Meta-Analysis, Alzheimer's Disease, Frontotemporal Dementia, Lewy Body Disease

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