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Identification of invasive subpopulations using spatial transcriptome analysis in thyroid follicular tumors
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논문 기본 정보

Type
Academic journal
Author
Ayana Suzuki (Osaka University) Satoshi Nojima (Osaka University) Shinichiro Tahara (Osaka University) Daisuke Motooka (Osaka University) Masaharu Kohara (Osaka University) Daisuke Okuzaki (Osaka University) Mitsuyoshi Hirokawa (Kuma Hospital) Eiichi Morii (Osaka University)
Journal
대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine Vol.58 No.1 KCI Accredited Journals
Published
2024.1
Pages
22 - 28 (7page)
DOI
10.4132/jptm.2023.11.21

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Identification of invasive subpopulations using spatial transcriptome analysis in thyroid follicular tumors
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Background: Follicular tumors include follicular thyroid adenomas and carcinomas; however, it is difficult to distinguish between the two when the cytology or biopsy material is obtained from a portion of the tumor. The presence or absence of invasion in the resected material is used to differentiate between adenomas and carcinomas, which often results in the unnecessary removal of the adenomas. If nodules that may be follicular thyroid carcinomas are identified preoperatively, active surveillance of other nodules as adenomas is possible, which reduces the risk of surgical complications and the expenses incurred during medical treatment. Therefore, we aimed to identify biomarkers in the invasive subpopulation of follicular tumor cells.Methods: We performed a spatial transcriptome analysis of a case of follicular thyroid carcinoma and examined the dynamics of CD74 expression in 36 cases.Results: We identified a subpopulation in a region close to the invasive area, and this subpopulation expressed high levels of CD74. Immunohistochemically, CD74 was highly expressed in the invasive and peripheral areas of the tumor.Conclusions: Although high CD74 expression has been reported in papillary and anaplastic thyroid carcinomas, it has not been analyzed in follicular thyroid carcinomas. Furthermore, the heterogeneity of CD74 expression in thyroid tumors has not yet been reported. The CD74-positive subpopulation identified in this study may be useful in predicting invasion of follicular thyroid carcinomas.
#Thyroid #Follicular carcinoma #Spatial transcriptome analysis #CD74 #Capsular invasion

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