지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.1
- 수록면
- 177 - 191 (15page)
- DOI
- 10.1038/s12276-023-01142-6
이용수
초록· 키워드
오류제보하기
Dysregulation of wild-type p53 turnover is a key cause of hepatocellular carcinoma (HCC), yet its mechanism remains poorly understood. Here, we report that WD repeat and SOCS box containing protein 2 (WSB2), an E3 ubiquitin ligase, is an independent adverse prognostic factor in HCC patients. WSB2 drives HCC tumorigenesis and lung metastasis in vitro and in vivo. Mechanistically, WSB2 is a new p53 destabilizer that promotes K48-linked p53 polyubiquitination at the Lys291 and Lys292 sites in HCC cells, leading to p53 proteasomal degradation. Degradation of p53 causes IGFBP3-dependent AKT/mTOR signaling activation. Furthermore, WSB2 was found to bind to the p53 tetramerization domain via its SOCS box domain. Targeting mTOR with everolimus, an oral drug, significantly blocked WSB2-triggered HCC tumorigenesis and metastasis in vivo. In clinical samples, high expression of WSB2 was associated with low wild-type p53 expression and high p-mTOR expression. These findings demonstrate that WSB2 is overexpressed and degrades wild-type p53 and then activates the IGFBP3-AKT/mTOR axis, leading to HCC tumorigenesis and lung metastasis, which indicates that targeting mTOR could be a new therapeutic strategy for HCC patients with high WSB2 expression and wild-type p53.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
WSB/BLT Trajectory Design using Poincaré Section in GMAT
한국항공우주학회 학술발표회 초록집
2021 .07
-
Isolation and Characterization of Water Soluble Bioactive Substances from Marine Photosynthetic Microalga Tetraselmis Species
Journal of Chitin and Chitosan
2017 .01
-
Hepatocellular carcinoma: old friends and new tricks
Experimental and Molecular Medicine
2020 .12
-
WSB/BLT 궤적 설계를 위한 달 궤도 조건
한국항공우주학회 학술발표회 초록집
2020 .11
-
시험용 달 궤도선의 분사오차와 기동시점을 고려한 WSB/BLT 궤적오차보정기동 분석
한국항공우주학회 학술발표회 초록집
2020 .11
-
Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells
BMB Reports
2016 .01
-
Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations
조직공학과 재생의학
2024 .01
-
Methylation-sensitive high-resolution melting analysis of the USP44 promoter can detect early-stage hepatocellular carcinoma in blood samples
BMB Reports
2022 .11
-
Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells
Experimental and Molecular Medicine
2020 .01
-
3D Structure Analysis Study of Hepatocellular Carcinoma (HCC) Biomarker NACA, NME2, PSMD4 for High Sensitivity HCC Diagnosis Sensor
한국생물공학회 학술대회
2015 .04
-
The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance
Experimental and Molecular Medicine
2016 .01
-
Loss of Pten synergizes with c-Met to promote hepatocellular carcinoma development via mTORC2 pathway
Experimental and Molecular Medicine
2018 .01
-
Cell Cycle Arrest Effects of Extract from Artemisia annuain through Akt/mTOR Signaling Pathway in HCT116 Colon Cancer Cells
한국생물공학회 학술대회
2015 .04
-
Apoptotic Effects of Extracts from Allium Hookeri through Regulating Akt/mTOR/p53 Signaling Pathways in AGS Human Gastric Carcinoma Cells
한국생물공학회 학술대회
2018 .04
-
Overexpression of CXCL2 inhibits cell proliferation and promotes apoptosis in hepatocellular carcinoma
BMB Reports
2018 .01
-
A gene expression signature of FOXM1 predicts the prognosis of hepatocellular carcinoma
Experimental and Molecular Medicine
2018 .01
-
SF3B4 as an early-stage diagnostic marker and driver of hepatocellular carcinoma
BMB Reports
2018 .01
-
HCT116 대장암세포에서 Akt-mTOR 신호경로를 통한 개똥쑥 추출물(AAE)의 세포주기 억제 효과
KSBB Journal
2015 .10
최근 본 자료
댓글(0)
0