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논문 기본 정보

자료유형
학술저널
저자정보
Heejin Park (Korea Institute of Toxicology (KIT)) Ju-Hye Kim (Korea Institute of Toxicology (KIT)) Mun-Hyoung Bae (Rpbio) Youngha Seo (Rpbio) Eun-Young Gu (Korea Institute of Toxicology (KIT)) Taek-Keun Oh (Chungnam National University) Byoung-Seok Lee (Korea Institute of Toxicology (KIT))
저널정보
충남대학교 농업과학연구소 Korean Journal of Agricultural Science Korean Journal of Agricultural Science Vol.51 No.2
발행연도
2024.6
수록면
147 - 158 (12page)

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초록· 키워드

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Hepatic fibrosis refers to the scarring of liver tissue, often resulting from chronic liver injury or inflammation. It is characterized by excessive deposition of extracellular matrix proteins, impairing liver function and potentially progressing to cirrhosis if left untreated. To improve the liver functions, Cordyceps militaris , a species of parasitic fungus known for its medicinal properties, is used in the form of extract. It has been traditionally used in Chinese medicine to boost energy, improve stamina, and support overall health. In this study, we investigated the hepatoprotective effects of Cordyceps militaris extract powder in a liver injury model induced by hepatic fibrosis. Sprague-Dawley (SD) rats were administered Dimethylnitrosamine (DMN) to induce liver injury, and the hepatoprotective effects of Cordyceps militaris extract powder intake were assessed by comparing changes in liver enzyme levels and histological observations. Rats injected with DMN were orally administered Cordyceps militaris extract powder at doses of 0, 125, 250, and 500 mg·kg<SUP>-1</SUP>·day<SUP>-1</SUP> for three weeks. After three weeks of treatment, no significant differences were observed in hematological, clinical chemical, organ weight, gross examination, or microscopic examination between the DMN-alone group and the Cordyceps militaris extract powder-treated group. In conclusion, hepatoprotective effects against DMN-induced liver injury in SD rats treated with Cordyceps militaris extract powder were not observed under this study condition.

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Abstract
Introduction
Materials and Methods
Results and Discussion
Conclusion
References

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