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논문 기본 정보

자료유형
학술저널
저자정보
Park Sungha (Yonsei University College of Medicine Seoul Republic of Korea) 임상현 (가톨릭대학교) Cho In-Jeong (Ewha Womans University College of Medicine) 김대희 (울산대학교) 박재형 (충남대학교) Chung Woo-Baek (Department of Internal Medicine Seoul St Mary’s Hospital The Catholic University Seoul South Korea) Choi Seonghoon (Kangnam Sacred Heart Hospital Hallym University College of Medicine Seoul South Korea) 이해영 (서울대학교) Kim Hyeon Chang (Department of Preventive Medicine Yonsei Universi) 손일석 (경희대학교) Lee Eun Mi (Wonkwang University Sanbon Hospital Gunpo Gyeonggi-do Republic of Korea) Kim Ju Han (Chonnam National University Hospital Gwangju Korea) 김광일 (Seoul National University Bundang Hospital) Cho Eun Joo (가톨릭대학교) 성기철 (성균관대학교) Shin Jinho (Hanyang University College of Medicine Seoul Republic of Korea) 편욱범 (이화여자대학교)
저널정보
대한고혈압학회 Clinical Hypertension Clinical Hypertension 제29권
발행연도
2023.1
수록면
25 - 25 (1page)
DOI
10.1186/s40885-023-00249-2

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초록· 키워드

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Nocturnal blood pressure (BP) has been shown to have a significant predictive value for cardiovascular disease. In some cases, it has a superior predictive value for future cardiovascular outcomes than daytime BP. As efficacy of BP medications wanes during nighttime and early morning, control of nocturnal hypertension and morning hypertension can be difficult. As such, chronotherapy, the dosing of BP medication in the evening, has been an ongoing topic of interest in the field of hypertension. Some studies have shown that chronotherapy is effective in reducing nocturnal BP, improving non dipping and rising patterns to dipping patterns, and improving cardiovascular prognosis. However, criticism and concerns have been raised regarding the design of these studies, such as the Hygia study, and the implausible clinical benefits in cardiovascular outcomes considering the degree of BP lowering from bedtime dosing. Studies have shown that there is no consistent evidence to suggest that routine administration of antihypertensive medications at bedtime can improve nocturnal BP and early morning BP control. However, in some cases of uncontrolled nocturnal hypertension and morning hypertension, such as in those with diabetes mellitus, chronic kidney disease, and obstructive sleep apnea, bedtime dosing has shown efficacy in reducing evening and early morning BP. The recently published the Treatment in Morning versus Evening (TIME) study failed to demonstrate benefit of bedtime dosing in reducing cardiovascular outcomes in patients with hypertension. With issues of the Hygia study and negative results from the TIME study, it is unclear at this time whether routine bedtime dosing is beneficial for reducing cardiovascular outcomes.

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