Hyperbaric oxygenation applied before or after mild or hard stress: effects on the redox state in the muscle tissue

Claudia Carolina Pérez-Castro; Alexandre Kormanovski; Gustavo Guevara-Balcázar; María del Carmen Castillo-Hernández; José Rubén García-Sánchez; Ivonne María Olivares-Corichi; Pedro López-Sánchez; Iván Rubio-Gayosso

doi:10.4196/kjpp.2023.27.1.9

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저자정보: Claudia Carolina Pérez-Castro (Escuela Superior de Medicina Sección de Estudio de Posgrado e Investigación Instituto Politécnico Nacional Mexico City 11340 Mexico) Alexandre Kormanovski (Escuela Superior de Medicina Sección de Estudio de Posgrado e Investigación Instituto Politécnico Nacional Mexico City 11340 Mexico) Gustavo Guevara-Balcázar (Escuela Superior de Medicina Sección de Estudio de Posgrado e Investigación Instituto Politécnico Nacional Mexico City 11340 Mexico) María del Carmen Castillo-Hernández (Escuela Superior de Medicina Sección de Estudio de Posgrado e Investigación Instituto Politécnico Nacional Mexico City 11340 Mexico) José Rubén García-Sánchez (Escuela Superior de Medicina Sección de Estudio de Posgrado e Investigación Instituto Politécnico Nacional Mexico City 11340 Mexico) Ivonne María Olivares-Corichi (Escuela Superior de Medicina Sección de Estudio de Posgrado e Investigación Instituto Politécnico Nacional Mexico City 11340 Mexico) Pedro López-Sánchez (Escuela Superior de Medicina Sección de Estudio de Posgrado e Investigación Instituto Politécnico Nacional Mexico City 11340 Mexico) Iván Rubio-Gayosso (Escuela Superior de Medicina Sección de Estudio de Posgrado e Investigación Instituto Politécnico Nacional Mexico City 11340 Mexico)

저널정보: 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제27권 제1호

발행연도: 2023.1

수록면: 9 - 20 (12page)

DOI: 10.4196/kjpp.2023.27.1.9

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The mechanism is unclear for the reported protective effect of hyperbaric oxygen preconditioning against oxidative stress in tissues, and the distinct effects of hyperbaric oxygen applied after stress. The trained mice were divided into three groups: the control, hyperbaric oxygenation preconditioning, and hyperbaric oxygenation applied after mild (fasting) or hard (prolonged exercise) stress. After preconditioning, we observed a decrease in basal levels of nitric oxide, tetrahydrobiopterin, and catalase despite the drastic increase in inducible and endothelial nitric oxide synthases. Moreover, the basal levels of glutathione, related enzymes, and nitrosative stress only increased in the preconditioning group. The control and preconditioning groups showed a similar mild stress response of the endothelial and neuronal nitric oxide synthases. At the same time, the activity of all nitric oxide synthase, glutathione (GSH) in muscle, declined in the experimental groups but increased in control during hard stress. The results suggested that hyperbaric oxygen preconditioning provoked uncoupling of nitric oxide synthases and the elevated levels of GSH in muscle during this study, while hyperbaric oxygen applied after stress showed a lower level of GSH but higher recovery post-exercise levels in the majority of antioxidant enzymes. We discuss the possible mechanisms of the redox response and the role of the nitric oxide in this process

#Glutathione #Hyperbaric oxygen #Mice #Nitric oxide #Nitic oxide synthase #Stress

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